Design, Synthesis and Application of Peroxynitrite Anion Fluorescent Probe with Large Stokes Shift
文献类型：期刊论文
| 作者 | Yang, Xin-Tong3; Wang, Xiao-Chun2; Ma, Cui-Ping3; Zhang, Liang-Wei1; Chen, Ling-Xin1 |
| 刊名 | CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
 |
| 出版日期 | 2025-07-01 |
| 卷号 | 53期号:7页码:1118-1126 |
| 关键词 | Fluorescent probe Peroxynitrite anion Large Stokes shift Cell imaging Oxidative stress |
| ISSN号 | 0253-3820 |
| DOI | 10.19756/j.issn.0253-3820.251147 |
| 通讯作者 | Wang, Xiao-Chun(wangwxc1120@163.com) ; Ma, Cui-Ping(mcp169@163.com) ; Chen, Ling-Xin(lxchen@yic.ac.cn) |
| 英文摘要 | Peroxynitrite anion (ONOO-), which is originated from the reaction of nitric oxide (NO) and superoxide anion (O-2(-)), plays a pivotal role in immune defense and signal regulation. Excessive levels of ONOO(- )may induce the occurrence of various diseases such as Alzheimer ' s disease, inflammation, cardiovascular disease and cancer, etc. Existing detection methods for ONOO(- )have limitations such as complexity, time consumption, and low cell biocompatibility. In this study, a novel fluorescent probe QFPD was developed using quinoline and diphenylphosphinamide as fluorescent keleton and recognition group, respectively. The strong oxidizing property of ONOO-triggerd the cleavage of phosphoramide bond, leading to fluorescence quenching and a visible color change of the solution from yellow to purple, thereby enabling "ON-OFF" type recognition of ONOO-.QFPD exhibited excellent characteristics including good selectivity and high sensitivity in fluorescence detection (Limit of detection of 1.37 mu mol/L), large Stokes shift (130 nm), rapid response (10 min), and strong anti-interference ability. Additionally, QFPD demonstrated good biocompatibility and could realize real-time dynamic monitoring of endogenous ONOO-.Furthermore, QFPD was successfully applied to environmental toxicology research by visualizing the oxidative stress effects induced by microplastics polymethyl methacrylate (PMMA) and Hg2+ exposure, which might be a novel tool for the mechanism research on oxidative stress associated with microplastic pollution and heavy metal exposure. |
| WOS关键词 | OXIDATIVE STRESS ; NITRIC-OXIDE |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001546967200001 |
| 资助机构 | National Natural Science Foundation of China ; Key Research and Development Program of Liaoning Province, China |
| 源URL | [http://ir.yic.ac.cn/handle/133337/40841]  |
| 专题 | 烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室 |
| 通讯作者 | Wang, Xiao-Chun; Ma, Cui-Ping; Chen, Ling-Xin |
| 作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 2.Anshan Normal Univ, Sch Chem & Life Sci, Liaoning Key Lab Dev & Utilizat Nat Prod Act Mol, Anshan 114007, Peoples R China 3.Qingdao Univ Sci & Technol, Coll Biol Engn, Qingdao 266042, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Xin-Tong,Wang, Xiao-Chun,Ma, Cui-Ping,et al. Design, Synthesis and Application of Peroxynitrite Anion Fluorescent Probe with Large Stokes Shift[J]. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,2025,53(7):1118-1126. |
| APA | Yang, Xin-Tong,Wang, Xiao-Chun,Ma, Cui-Ping,Zhang, Liang-Wei,&Chen, Ling-Xin.(2025).Design, Synthesis and Application of Peroxynitrite Anion Fluorescent Probe with Large Stokes Shift.CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,53(7),1118-1126. |
| MLA | Yang, Xin-Tong,et al."Design, Synthesis and Application of Peroxynitrite Anion Fluorescent Probe with Large Stokes Shift".CHINESE JOURNAL OF ANALYTICAL CHEMISTRY 53.7(2025):1118-1126. |
入库方式： OAI收割
来源：烟台海岸带研究所
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