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Elevated Levels of Foreign Microparticles in the Blood of Patients with Digestive System Diseases

文献类型：期刊论文

作者Song, Jie2,4; Wang, Yunqing1,3; Ji, Yunxia2,4; Wang, Meirong2; Yuan, Qi3; Lv, Changjun4; Chen, Lingxin1,3
刊名ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS
出版日期2025-04-14
卷号12期号:5页码:503-509
关键词Digestive system diseases Blood Microparticleidentification Microplastics Raman detection
ISSN号2328-8930
DOI10.1021/acs.estlett.5c00262
通讯作者Wang, Yunqing(yqwang@yic.ac.cn) ; Lv, Changjun(lucky_lcj@sina.com) ; Chen, Lingxin(lxchen@yic.ac.cn)
英文摘要Exogenous microparticles can penetrate the bloodstream through the digestive tract, causing systemic toxic effects, but this phenomenon has long been overlooked. Digestive disease patients, as a vulnerable group, have not been adequately studied regarding blood particulate pollution compared to healthy individuals. In this study, blood samples from 26 patients with digestive system diseases and 29 healthy controls were collected, and a method for blood sample digestion and microparticle separation was developed. Employing Raman spectroscopy, laser-induced breakdown spectroscopy, and scanning electron microscopy with energy dispersive X-ray spectroscopy, 7 types of materials were identified from 846 observed microparticles, including calcium carbonate, phthalocyanine, iron sesquioxide, and carbon. Notably, this study for the first time revealed that patients with digestive system diseases had a significantly higher quantity and larger size of exogenous microparticles in their blood. This implies that digestive diseases might enhance the nonselective gut permeability to microparticles and the risk of systemic organ exposure to particulate pollution. These findings offer new insights into the mechanisms of particulate transport within the body and provide valuable evidence for understanding the pathogenesis of complications in digestive diseases (such as thrombosis) and dietary recommendations for patients.
WOS关键词QUANTITATIVE-ANALYSIS ; RAMAN-SPECTRA ; MICROPLASTICS ; EXTRACTION ; IDENTIFICATION ; NANOPARTICLES ; SPECTROSCOPY ; PROTOCOL ; BARRIER
WOS研究方向Engineering ; Environmental Sciences & Ecology
语种英语
WOS记录号WOS:001466581600001
资助机构National Natural Science Foundation of China ; National Natural Science Foundation of China ; Taishan Scholar Project Special Funding ; Special Fund for Leading Scholar Program of Yantai
源URL[http://ir.yic.ac.cn/handle/133337/40867]  
专题烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室
通讯作者Wang, Yunqing; Lv, Changjun; Chen, Lingxin
作者单位1.Shaoxing Univ, Coll Chem & Chem Engn, Shaoxing 312000, Peoples R China
2.Binzhou Med Univ, Sch Pharmaceut Sci, Dept Cellular & Genet Med, Yantai 264003, Peoples R China
3.Chinese Acad Sci, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
4.Binzhou Med Univ, Binzhou Med Univ Hosp, Dept Resp & Crit Care Med, Binzhou 256603, Peoples R China
推荐引用方式
GB/T 7714		 Song, Jie,Wang, Yunqing,Ji, Yunxia,et al. Elevated Levels of Foreign Microparticles in the Blood of Patients with Digestive System Diseases[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS,2025,12(5):503-509.
APA Song, Jie.,Wang, Yunqing.,Ji, Yunxia.,Wang, Meirong.,Yuan, Qi.,...&Chen, Lingxin.(2025).Elevated Levels of Foreign Microparticles in the Blood of Patients with Digestive System Diseases.ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS,12(5),503-509.
MLA Song, Jie,et al."Elevated Levels of Foreign Microparticles in the Blood of Patients with Digestive System Diseases".ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS 12.5(2025):503-509.

入库方式： OAI收割

来源：烟台海岸带研究所

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