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Study on the antioxidant defense of Pacific oysters (Crassostrea gigas) against sulfonamide antibiotics

文献类型：期刊论文

作者Chen, Hao3,5; You, Liping3; Sun, Jing3; Yu, Hao3; Sun, Wei3; Song, Changlin1,4; Su, Bo3; Ji, Chenglong1,2,4; Ye, Lin3,5; Li, Shujun3
刊名AQUACULTURE
出版日期2025-09-15
卷号607页码:15
关键词Sulfonamide antibiotics Crassostrea gigas Biotoxic effect Antioxidant defense
ISSN号0044-8486
DOI10.1016/j.aquaculture.2025.742651
通讯作者You, Liping(youliping521@163.com) ; Ma, Yuanqing(mayuanqing@shandong.cn)
英文摘要In this study, the impact of four sulfonamide antibiotics on the antioxidant defense mechanisms of the Pacific oyster (Crassostrea gigas) were detected. The exposure concentrations were set at 5 mu g/L and 500 mu g/L, based on the concentrations of sulfonamide antibiotics that have been investigated in the marine environment. The experiment was conducted at 48-h and 14-day exposure to the antibiotics, and bacterium stimulation by Vibrio parahaemolyticus after the exposure. The results showed that the oysters exhibited varying degrees of bioaccumulation for different sulfonamide antibiotics, though all bioconcentration factors (BCFs) remained below the threshold of 1000 (L/kg). However, given that oysters in natural environments are exposed to these antibiotics for significantly longer durations than in this experiment, the potential health risks associated with consuming sulfonamide-contaminated oysters cannot be overlooked. Additionally, research findings demonstrated that sulfonamide antibiotics trigger unique antioxidative responses within specific oyster tissues. These compounds catalyze notable shifts in SOD, CAT, and GPx enzyme activities, alongside MDA levels, with variations distinctly observed across different tissue types. The biotoxic effect of antibiotics on the oyster gills was lower than that on the hepatopancreas. The low concentrations of sulfonamide antibiotics exposure could induce antioxidant defences in the gills, but did not cause severe oxidative damage. While, high concentrations exposure could cause hepatopancreas oxidative damage. Among the four sulfonamide antibiotics, the potential biotoxic effect of sulphadoxine (SDX) was the highest, followed by sulfamethazine (SMT), sulfamonomethoxine (SMM), and sulfamethoxazole (SMX), while the biological oxidative stress responses of oysters to SMM and SMT were earlier than those of SMX and SDX.
WOS关键词OXIDATIVE STRESS ; OXIDE NANOPARTICLES ; BIOMARKER RESPONSES ; EXPOSURE ; BIOACCUMULATION ; SULFAMETHAZINE ; ENVIRONMENT ; LIVER ; OVARY
WOS研究方向Fisheries ; Marine & Freshwater Biology
语种英语
WOS记录号WOS:001485787900002
资助机构Shandong Provincial Key Research and Development Program ; National Key Research and Development Program ; Funda-mental Research Projects of Science and Technology Innovation and Development Plan in Yantai City
源URL[http://ir.yic.ac.cn/handle/133337/40960]  
专题烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室
通讯作者You, Liping; Ma, Yuanqing
作者单位1.YICCAS, Shandong Key Lab Coastal Environm Proc, Yantai 264003, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Shandong Marine Resource & Environm Res Inst, Shandong Key Lab Marine Ecol Restorat, Observat & Res Stn Laizhou Bay Marine Ecosyst, MNR, 216 Changjiang Rd, Yantai 264006, Peoples R China
4.Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai, Peoples R China
5.Shanghai Ocean Univ, Coll Oceanog & Ecol Sci, Shanghai 201306, Peoples R China
推荐引用方式
GB/T 7714		 Chen, Hao,You, Liping,Sun, Jing,et al. Study on the antioxidant defense of Pacific oysters (Crassostrea gigas) against sulfonamide antibiotics[J]. AQUACULTURE,2025,607:15.
APA Chen, Hao.,You, Liping.,Sun, Jing.,Yu, Hao.,Sun, Wei.,...&Ma, Yuanqing.(2025).Study on the antioxidant defense of Pacific oysters (Crassostrea gigas) against sulfonamide antibiotics.AQUACULTURE,607,15.
MLA Chen, Hao,et al."Study on the antioxidant defense of Pacific oysters (Crassostrea gigas) against sulfonamide antibiotics".AQUACULTURE 607(2025):15.

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来源：烟台海岸带研究所

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