The utilization of TGase-crosslinked phycocyanin-collagen hydrogels for the purpose of facilitating skin wound healing
文献类型：期刊论文
| 作者 | Qu, Jinqi2,4; Geng, Xinrong2,3; Qin, Song2,4; Li, Jie1; Li, Wenjun2,3,4 |
| 刊名 | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
 |
| 出版日期 | 2025-08-01 |
| 卷号 | 320页码:15 |
| 关键词 | Collagen Phycocyanin Hydrogel Wound healing |
| ISSN号 | 0141-8130 |
| DOI | 10.1016/j.ijbiomac.2025.145932 |
| 通讯作者 | Li, Jie(lijie@sdust.edu.cn) ; Li, Wenjun(wjli@yic.ac.cn) |
| 英文摘要 | Conventional collagen hydrogels face limitations such as residual toxicity from chemical cross-linkers (e.g., glutaraldehyde), inadequate antioxidant capacity, and poor permeability. To address these, we developed a phycocyanin-collagen hydrogel (PC-Col hydrogel ) using non-toxic transglutaminase (TGase) as a cross-linker. Results showed that, compared to collagen-only hydrogels, TGase-crosslinked PC-Col hydrogels exhibited enhanced thermal stability, superior permeability, and pH-responsive swelling (peak swelling rate: 358.54 % at pH 8.2). In vitro assays confirmed biocompatibility and dose-dependent improvement in cell migration. In rat wound models, PC-Col hydrogels increased CD-31 expression by 1.3-fold, reduced IL-6 and TNF-alpha levels by 28 % and 25 %, respectively, elevated CAT and SOD activities by 69 % and 45 %, and decreased MDA by 20 %. These results demonstrate that TGase-crosslinked PC-Col hydrogels offer enhanced permeability, anti-inflammatory efficacy, and antioxidant activity, validating their potential as advanced wound dressings. |
| WOS关键词 | C-PHYCOCYANIN ; PHYSICAL-PROPERTIES ; IN-VIVO ; TRANSGLUTAMINASE ; PROTEIN |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001549973100001 |
| 资助机构 | National Key Research and Development Program of China ; Special Plan for Major Scientific and Technological Innovation in Qingdao West Coast |
| 源URL | [http://ir.yic.ac.cn/handle/133337/41022]  |
| 专题 | 海岸带生物学与生物资源利用重点实验室 |
| 通讯作者 | Li, Jie; Li, Wenjun |
| 作者单位 | 1.Shandong Univ Sci & Technol, Qingdao 266590, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 3.Shandong Univ Tradit Chinese Med, Inst Marine Tradit Chinese Med, Qingdao 266112, Shandong, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qu, Jinqi,Geng, Xinrong,Qin, Song,et al. The utilization of TGase-crosslinked phycocyanin-collagen hydrogels for the purpose of facilitating skin wound healing[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2025,320:15. |
| APA | Qu, Jinqi,Geng, Xinrong,Qin, Song,Li, Jie,&Li, Wenjun.(2025).The utilization of TGase-crosslinked phycocyanin-collagen hydrogels for the purpose of facilitating skin wound healing.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,320,15. |
| MLA | Qu, Jinqi,et al."The utilization of TGase-crosslinked phycocyanin-collagen hydrogels for the purpose of facilitating skin wound healing".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 320(2025):15. |
入库方式： OAI收割
来源：烟台海岸带研究所
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