Dual responsive fluorescent probe for exploring hypochlorite and sulfur dioxide in different heavy metal ions related stress models
文献类型：期刊论文
| 作者 | Zhang, Li1,5; Tan, Jiangkun1,5; Yang, Xintong1; Fang, Shujing1; Wei, Shaoyu1,5; Liu, Shudi3; Zhang, Liangwei1,5; Wang, Xiaoyan4; Chen, Lingxin1,2,5,6 |
| 刊名 | JOURNAL OF HAZARDOUS MATERIALS
 |
| 出版日期 | 2025-09-15 |
| 卷号 | 496页码:10 |
| 关键词 | Redox homeostasis Dual-channel Fluorescence imaging Co-exposure |
| ISSN号 | 0304-3894 |
| DOI | 10.1016/j.jhazmat.2025.139543 |
| 通讯作者 | Zhang, Liangwei(liangweizhang@yic.ac.cn) ; Wang, Xiaoyan(wangxy@yic.ac.cn) ; Chen, Lingxin(lxchen@yic.ac.cn) |
| 英文摘要 | The danger of heavy metal pollution has drawn the global concern of researchers in recent decades, especially multiple heavy metal pollution. Heavy metal pollution induced stress may cause oxidative stress and redox balance disruption in living organism, and further trigger other secondary stresses. Fluorescent imaging analysis is considered to be effective method for real-time visualization of complex bioactive molecules in situ due to their non-destruction, high sensitivity and specificity. It is still relatively rare that bifunctional fluorescent probe for imaging redox-correlated molecules under heavy metal stress. Herein, we designed and synthesized a smart dual responsive fluorescence probe (D-P) with dual detection sites for the individual detection of HClO and SO2 derivatives with different channels. The probe D-P was applied to effectively dual monitor the dynamic change of HClO and SO2 derivatives in plant, zebrafish and human cells. Importantly, probe D-P successfully observed dynamic changes of HClO and SO2 derivatives mediated redox status in living organisms under single and combined exposure to heavy metal stress, and further during DTT-induced ER stress and hypoxia and ischemia stress, confirming that probe D-P is a powerful tool to real-time image of the dynamic balance of HClO and SO2 derivatives for assessing the redox homeostasis under environmental stress, which can be monitored and adopted as the early warning in environmental stress conditions and disease. |
| WOS关键词 | DERIVATIVES ; CELLS ; HCLO ; CD2+ |
| WOS研究方向 | Engineering ; Environmental Sciences & Ecology |
| 语种 | 英语 |
| WOS记录号 | WOS:001555806200001 |
| 资助机构 | National Natural Science Foundation of China ; Program of Youth Innovation Promotion Association, CAS ; Taishan Scholar Project Special Funding |
| 源URL | [http://ir.yic.ac.cn/handle/133337/41040]  |
| 专题 | 烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室 |
| 通讯作者 | Zhang, Liangwei; Wang, Xiaoyan; Chen, Lingxin |
| 作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Shandong Key Lab Coastal Environm Proc, Yantai 264003, Peoples R China 2.Qingdao Marine Sci & Technol Ctr, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China 3.Yantai Univ, Coll Chem & Chem Engn, Yantai 264005, Peoples R China 4.Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China 5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 6.Shaoxing Univ, Inst Adv Study, Shaoxing 312000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Li,Tan, Jiangkun,Yang, Xintong,et al. Dual responsive fluorescent probe for exploring hypochlorite and sulfur dioxide in different heavy metal ions related stress models[J]. JOURNAL OF HAZARDOUS MATERIALS,2025,496:10. |
| APA | Zhang, Li.,Tan, Jiangkun.,Yang, Xintong.,Fang, Shujing.,Wei, Shaoyu.,...&Chen, Lingxin.(2025).Dual responsive fluorescent probe for exploring hypochlorite and sulfur dioxide in different heavy metal ions related stress models.JOURNAL OF HAZARDOUS MATERIALS,496,10. |
| MLA | Zhang, Li,et al."Dual responsive fluorescent probe for exploring hypochlorite and sulfur dioxide in different heavy metal ions related stress models".JOURNAL OF HAZARDOUS MATERIALS 496(2025):10. |
入库方式： OAI收割
来源：烟台海岸带研究所
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