Modified Fish-Skin-Collagen-Based Hydrogels with Antioxidant and Antibacterial Functions for Diabetic Wound Healing
文献类型：期刊论文
| 作者 | Geng, Xinrong1,5,6; Li, Wenjun1,5,6; Qu, Jinqi1,4; Wang, Qi1,6; Che, Tuanjie3,5; Yan, Libo3,5; Cui, Hongli1; Liu, Dongting2; Qin, Song1,5,6 |
| 刊名 | ADVANCED HEALTHCARE MATERIALS
 |
| 出版日期 | 2025-06-16 |
| 页码 | 20 |
| 关键词 | diabetic wounds ferroptosis fish skin collagen iron homeostasis protocatechualdehyde |
| ISSN号 | 2192-2640 |
| DOI | 10.1002/adhm.202501456 |
| 通讯作者 | Qin, Song(sqin@yic.ac.cn) |
| 英文摘要 | Chronic wound management in diabetes represents a significant global medical challenge, primarily due to the complex microenvironment of diabetic wounds. Recently, fish-skin-collagen (Co)-based hydrogels have gained attention for treating skin wounds. However, their application in diabetic wounds has been restricted by their limited antibacterial properties, mechanical strength, and thermal stability. Here, a Co-based hydrogel (CFP) is developed, cross-linked via Co and a protocatechualdehyde-iron(III) Complex chelate (PCA@Fe) formed between protocatechualdehyde (PCA) and ferric ion (Fe3+). The CFP enhances its mechanical properties and thermal stability by forming Schiff base bonds between PCA@Fe and Co, while endowing itself with self-healing ability and photothermal effect. Co promotes angiogenesis and collagen remodeling, while PCA inhibits ferroptosis in cells and disrupts bacterial iron homeostasis, thereby suppressing the oxidative stress and bacterial infection in diabetic wounds. Furthermore, the photothermal effect synergizing with the disruption of bacterial iron homeostasis significantly reduces bacterial infections in diabetic wounds, thereby accelerating the healing process of chronic diabetic wounds. |
| WOS关键词 | ANESTHETICS ; MANAGEMENT |
| WOS研究方向 | Engineering ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001508700700001 |
| 资助机构 | Special Plan for Major Scientific and Technological Innovation in Qingdao West Coast ; Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences |
| 源URL | [http://ir.yic.ac.cn/handle/133337/41133]  |
| 专题 | 海岸带生物学与生物资源利用重点实验室 |
| 通讯作者 | Qin, Song |
| 作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Shandong, Peoples R China 2.Qingdao Municipal Hosp, Qingdao 266000, Shandong, Peoples R China 3.Zhigong Biomed Co Ltd, Yantai 264035, Shandong, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai Ctr Technol Innovat Coastal Zone Biol Resou, Yantai 264003, Shandong, Peoples R China 6.Shandong Univ Tradit Chinese Med, Inst Marine Tradit Chinese Med, Qingdao 266112, Shandong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Geng, Xinrong,Li, Wenjun,Qu, Jinqi,et al. Modified Fish-Skin-Collagen-Based Hydrogels with Antioxidant and Antibacterial Functions for Diabetic Wound Healing[J]. ADVANCED HEALTHCARE MATERIALS,2025:20. |
| APA | Geng, Xinrong.,Li, Wenjun.,Qu, Jinqi.,Wang, Qi.,Che, Tuanjie.,...&Qin, Song.(2025).Modified Fish-Skin-Collagen-Based Hydrogels with Antioxidant and Antibacterial Functions for Diabetic Wound Healing.ADVANCED HEALTHCARE MATERIALS,20. |
| MLA | Geng, Xinrong,et al."Modified Fish-Skin-Collagen-Based Hydrogels with Antioxidant and Antibacterial Functions for Diabetic Wound Healing".ADVANCED HEALTHCARE MATERIALS (2025):20. |
入库方式： OAI收割
来源：烟台海岸带研究所
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