Evaluating the "double-edged sword" effects of sulfur dioxide on lung tissue inflammation via fluorescent probe
文献类型：期刊论文
| 作者 | Zhang, Xia5; Zhou, Tong5; Liu, Shudi3; Wang, Yuran5; Li, Youjie5; Wang, Ranran5; Wang, Pingyu2,5; Chen, Lingxin1; Xie, Shuyang4,5 |
| 刊名 | MICROCHEMICAL JOURNAL
 |
| 出版日期 | 2025-08-01 |
| 卷号 | 215页码:9 |
| 关键词 | Fluorescent imaging Inflammation Dual effects Lung tissue SO 2 derivatives |
| ISSN号 | 0026-265X |
| DOI | 10.1016/j.microc.2025.114303 |
| 通讯作者 | Wang, Pingyu(wangpingyu@bzmc.edu.cn) ; Chen, Lingxin(lxchen@yic.ac.cn) ; Xie, Shuyang(xieshuyang@bzmc.edu.cn) |
| 英文摘要 | Sulfur dioxide (SO2), a pungent toxic gaseous pollutant, excessively exposed to organism would stimulate respiratory system and cause inflammation and other respiratory diseases. Endogenous SO2 mainly generates from sulfur-containing amino acids and also maintains reactive sulfur species metabolic balance as an important signaling molecule. Although great progress of current SO2 detection analysis has been made via fluorescence probe, visualized evidence for the research of inflammation and other diseases in respiratory caused by SO2 is scarce. Developing powerful analysis tools to investigate SO2 function on the respiratory system is still necessary. Herein, we designed a simple fluorescent probe OPD-SO2 for evaluating the effects of SO2 on lung tissue inflammation. OPD-SO2 provides visualized evidences for elevating SO2 in aspartate aminotransferase-1 (AAT1) gene over-expressed common/inflammatory cells, and verifies that inflammation occurrence promoted SO2 generation and AAT1-overexpressed cells might resist inflammation by up-regulating intracellular SO2, exhibits favorable detectability of SO2 in bronchoalveolar lavage fluid of SO2 exposed mice. The inflammation state related to SO2 levels before and after anti-inflammatory treatment has also been investigated. Moreover, the evaluation assisted by PCR, ELISA, and histopathologic analysis reveals the dual effects between SO2 levels and lung tissue inflammatory. |
| WOS关键词 | INJURY ; DERIVATIVES ; SO2 |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001520611800001 |
| 资助机构 | National Natural Science Foundation of China ; Natural Science Foundation of Shandong ; Education Department of Shan-dong Province ; Science Fund of Shandong Lab-oratory of Advanced Materials and Green Manufacturing (Yantai) |
| 源URL | [http://ir.yic.ac.cn/handle/133337/41163]  |
| 专题 | 烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室 |
| 通讯作者 | Wang, Pingyu; Chen, Lingxin; Xie, Shuyang |
| 作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res Ctr Coastal Environm Engn & Technol, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China 2.Binzhou Med Univ, Dept Epidemiol, Yantai 264003, Peoples R China 3.Yantai Univ, Coll Chem & Chem Engn, Yantai 264005, Peoples R China 4.Shandong Lab Adv Mat & Green Mfg, Yantai 264000, Peoples R China 5.Binzhou Med Univ, Dept Biochem & Mol Biol, Yantai 264003, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Xia,Zhou, Tong,Liu, Shudi,et al. Evaluating the "double-edged sword" effects of sulfur dioxide on lung tissue inflammation via fluorescent probe[J]. MICROCHEMICAL JOURNAL,2025,215:9. |
| APA | Zhang, Xia.,Zhou, Tong.,Liu, Shudi.,Wang, Yuran.,Li, Youjie.,...&Xie, Shuyang.(2025).Evaluating the "double-edged sword" effects of sulfur dioxide on lung tissue inflammation via fluorescent probe.MICROCHEMICAL JOURNAL,215,9. |
| MLA | Zhang, Xia,et al."Evaluating the "double-edged sword" effects of sulfur dioxide on lung tissue inflammation via fluorescent probe".MICROCHEMICAL JOURNAL 215(2025):9. |
入库方式： OAI收割
来源：烟台海岸带研究所
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