Chinese medicine preparation Pudilan anti-inflammatory oral liquid: Chemical constituents and developmental toxicity
文献类型：期刊论文
| 作者 | Chen, Jingjing2,5; Lu, Zhen5; Yan, Zhi5; Li, Yaxi5; Hou, Zhihao5; Wang, Derui4,5; Jiang, Yanqiu3; Zhang, Ranran5; Li, Xiaodong5; Jiang, Baozhen5 |
| 刊名 | JOURNAL OF ETHNOPHARMACOLOGY
 |
| 出版日期 | 2025-07-24 |
| 卷号 | 351页码:12 |
| 关键词 | Embryos development Locomotion Hyperpigmentation Transcriptomic analysis |
| ISSN号 | 0378-8741 |
| DOI | 10.1016/j.jep.2025.120173 |
| 通讯作者 | Li, Ke(kli@yic.ac.cn) |
| 英文摘要 | Ethnopharmacological relevance: Pudilan anti-inflammatory oral liquid (PDL) is a classical Chinese herbal formulation. Traditionally used to treat respiratory infections, sore throat, and mumps, it is widely administered in children and pregnant women due to its perceived safety. However, recent guidelines advise caution in these populations, raising concern about its developmental toxicity. This study investigates the chemical profile and embryotoxic effects of PDL to bridge traditional use with modern toxicological evaluation. Aims of the study: To identify the chemical constituents of PDL and evaluate its developmental toxicity, as well as elucidate potential toxicological mechanisms using a zebrafish embryo model. Materials and methods: The chemical composition of PDL was characterized using ultra-high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-QTOF-MS). Zebrafish (Danio rerio) embryos were exposed to various PDL concentrations. Developmental toxicity was assessed through mortality, malformation, hatching, heart rate, body length, spontaneous movement, and locomotor activity. Histological analysis, transcriptomic profiling, and qRT-PCR validation were conducted to explore underlying mechanisms. Results: Baicalin was identified as the dominant flavonoid, followed by baicalein and wogonin. PDL exposure induced dose-dependent developmental toxicity, including increased mortality, malformations, and impaired cardiac and behavioral functions. Transcriptomic analysis revealed dysregulation in cell cycle, DNA replication, and steroid biosynthesis pathways. Conclusion: PDL exhibits significant embryotoxicity in zebrafish, potentially mediated by flavonoid-induced disruption of developmental pathways. These findings highlight the need for safety assessments of traditional formulations, particularly in vulnerable populations. |
| WOS关键词 | VITAMIN-D ; ZEBRAFISH ; BAICALEIN ; WOGONIN ; STRESS |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:001520474700001 |
| 资助机构 | National Natural Science Foundation of China ; Seed project of Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences ; Yantai Science and Technology Innovation Development Program |
| 源URL | [http://ir.yic.ac.cn/handle/133337/41166]  |
| 专题 | 海岸带生物学与生物资源利用重点实验室 |
| 通讯作者 | Li, Ke |
| 作者单位 | 1.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China 2.Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China 3.Shanghai Ocean Univ, Key Lab Freshwater Aquat Genet Resources, Minist Agr & Rural Affairs, Shanghai 210306, Peoples R China 4.Beibu Gulf Univ, Coll Marine Sci, Qinzhou 535011, Peoples R China 5.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Jingjing,Lu, Zhen,Yan, Zhi,et al. Chinese medicine preparation Pudilan anti-inflammatory oral liquid: Chemical constituents and developmental toxicity[J]. JOURNAL OF ETHNOPHARMACOLOGY,2025,351:12. |
| APA | Chen, Jingjing.,Lu, Zhen.,Yan, Zhi.,Li, Yaxi.,Hou, Zhihao.,...&Li, Ke.(2025).Chinese medicine preparation Pudilan anti-inflammatory oral liquid: Chemical constituents and developmental toxicity.JOURNAL OF ETHNOPHARMACOLOGY,351,12. |
| MLA | Chen, Jingjing,et al."Chinese medicine preparation Pudilan anti-inflammatory oral liquid: Chemical constituents and developmental toxicity".JOURNAL OF ETHNOPHARMACOLOGY 351(2025):12. |
入库方式： OAI收割
来源：烟台海岸带研究所
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