Cytokine Storm Induction Linked to Multi-Organ Failure in Fatal Jellyfish Stings
文献类型：期刊论文
| 作者 | Wang, Yichao8,9; Wang, Yi7,9; Yang, Fengling5,6,9; Chen, Jingbo9; Geng, Xiaoyu9; Sun, Qing4; Zhang, Jinyu9; Liu, Chang7,9; Lv, Jie9; Hou, Xiaochuan9 |
| 刊名 | ADVANCED SCIENCE
 |
| 出版日期 | 2025-07-13 |
| 页码 | 12 |
| 关键词 | cytokine storm envenomation inflammation jellyfish NF-kappa B p65 |
| DOI | 10.1002/advs.202501104 |
| 通讯作者 | Chen, Lingxin(lxchen@yic.ac.cn) ; Yan, Bing(drbingyan@gzhu.edu.cn) ; Xiao, Liang(hormat830713@hotmail.com) |
| 英文摘要 | Fatal jellyfish stings often cause multi-organ failure. Until now, these fatal outcomes are attributed to the direct toxic effects of the venom. Here, a mouse model of delayed jellyfish envenomation syndrome (DJES) is established and showed that venom from Nemopilema nomurai jellyfish can trigger a deadly cytokine storm - a severe inflammatory reaction. Mice injected with the venom displayed acute multi-organ failure and significant upregulation of over 20 pro-inflammatory cytokines (including IL-6, TNF-alpha, CXCL2, and CCL4) in the heart, liver, and kidneys. Transcriptomic analyses identified NF-kappa B p65 subunit activation as central to the cytokine storm induction. Knockdown of p65 in macrophages reduced cytokine production and improved cell viability. Treatment with dexamethasone, an NF-kappa B inhibitor, effectively suppressed the cytokine storm, mitigated organ damage, and increased survival rates in mice. The findings present new insights to treat fatal jellyfish stings. |
| WOS关键词 | NF-KAPPA-B ; TENTACLE EXTRACT ; DEXAMETHASONE ; EXPRESSION ; CELLS ; VENOM ; DYSFUNCTION ; TOXICITY ; IMMUNITY ; MURINE |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001527386600001 |
| 资助机构 | Shanghai's Science and Technology Innovation Action Plan International Science and Technology Cooperation Project ; National Key R&D Plan of the Ministry of Science and Technology Sino US International Cooperation Project ; Shanghai Municipal Health Commission Research Project Fund |
| 源URL | [http://ir.yic.ac.cn/handle/133337/41215]  |
| 专题 | 烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室 |
| 通讯作者 | Chen, Lingxin; Yan, Bing; Xiao, Liang |
| 作者单位 | 1.Guangzhou Univ, Minist Educ, Inst Environm Res Greater Bay Area, Key Lab Water Qual & Conservat Pearl River Delta, Guangzhou 510006, Guangdong, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res Ctr Coastal Environm Engn & Technol, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Shandong, Peoples R China 3.971 Hosp PLA Navy, Dept Intens Care Med, Qingdao 266071, Shandong, Peoples R China 4.971 Hosp PLA Navy, Dept Mil & Special Med, Qingdao 266071, Shandong, Peoples R China 5.Second Mil Med Univ, Shanghai Key Lab Med Bioprotect, Shanghai 200433, Peoples R China 6.Second Mil Med Univ, Minist Educ, Key Lab Biol Def, Shanghai 200433, Peoples R China 7.Jilin Agr Univ, Coll Tradit Chinese Med, Changchun 130118, Jilin, Peoples R China 8.First Peoples Hosp Xianyang, Dept Clin Lab, Xianyang 712000, Shannxi, Peoples R China 9.Naval Med Univ, Fac Naval Med, Shanghai 200433, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Yichao,Wang, Yi,Yang, Fengling,et al. Cytokine Storm Induction Linked to Multi-Organ Failure in Fatal Jellyfish Stings[J]. ADVANCED SCIENCE,2025:12. |
| APA | Wang, Yichao.,Wang, Yi.,Yang, Fengling.,Chen, Jingbo.,Geng, Xiaoyu.,...&Xiao, Liang.(2025).Cytokine Storm Induction Linked to Multi-Organ Failure in Fatal Jellyfish Stings.ADVANCED SCIENCE,12. |
| MLA | Wang, Yichao,et al."Cytokine Storm Induction Linked to Multi-Organ Failure in Fatal Jellyfish Stings".ADVANCED SCIENCE (2025):12. |
入库方式： OAI收割
来源：烟台海岸带研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。