Metagenomics-Metabolomics Reveals the Alleviation of Indole-3-Ethanol on Radiation-Induced Enteritis in Mice
文献类型：期刊论文
| 作者 | Zhong, Hua1,2; Song, Yipeng3; Hu, Shanliang3; Zhang, Chengxu3; Li, Lili2 |
| 刊名 | JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
 |
| 出版日期 | 2025 |
| 卷号 | 35页码:14 |
| 关键词 | Gut microbiota metabolites radiation enteritis radiotherapy indole-3-ethanol |
| ISSN号 | 1017-7825 |
| DOI | 10.4014/jmb.2502.02037 |
| 通讯作者 | Li, Lili(llli@yic.ac.cn) |
| 英文摘要 | Indole-3-ethanol (IEt), a small molecule metabolite from intestinal microbial tryptophan metabolism, has been established to have anti-inflammatory properties. However, its effect on radiation-induced enteritis has not been reported. Here, we aim to explore the effects and potential mechanisms of IEt on radiation enteritis. C57BL/6J mice were orally administered an IEt solution before radiation exposure. Inflammatory factors, including IL-17A, IFN-gamma, IL-6 and IL-1 beta, were detected using enzyme-linked immunosorbent assay. Colonic histopathology was assessed through H&E staining. Subsequently, gut microbiota and its metabolites were analyzed using metagenomics and metabolomics. The results suggested that IEt alleviated radiation-induced enteritis, as evidenced by improved colonic structural integrity, decreased levels of pro-inflammatory factors like IL-17A, and the restoration of intestinal microecological and metabolic balance. IEt enriched the abundance of Lachnospiraceae family members, particularly the genus Roseburia-a known anti-inflammatory commensal. In addition, IEt upregulated the levels of metabolites with anti-inflammatory effects such as indole-3-carbinol, pteridine, and pyropheophorbide-a. Furthermore, Roseburia was significantly positively correlated with indole-3-carbinol and negatively correlated with the pro-inflammatory factor IL-17A. Therefore, IEt may alleviate radiation enteritis through Roseburia-indole-3-carbinol and Roseburia-IL-17A axes. This study revealed the potential mechanisms by which IEt alleviated radiation enteritis, providing a potential protective candidate for radiation enteritis. |
| WOS关键词 | INDOLE-3-CARBINOL ; METABOLITES |
| WOS研究方向 | Biotechnology & Applied Microbiology ; Microbiology |
| 语种 | 英语 |
| WOS记录号 | WOS:001540778200013 |
| 资助机构 | National Key Research and Development Program of China ; Technical Support Talents of Chinese Academy of Sciences |
| 源URL | [http://ir.yic.ac.cn/handle/133337/41230]  |
| 专题 | 海岸带生物学与生物资源利用重点实验室 |
| 通讯作者 | Li, Lili |
| 作者单位 | 1.Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 3.Yantai Yuhuangding Hosp, Dept Radiotherapy, Yantai 264000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhong, Hua,Song, Yipeng,Hu, Shanliang,et al. Metagenomics-Metabolomics Reveals the Alleviation of Indole-3-Ethanol on Radiation-Induced Enteritis in Mice[J]. JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY,2025,35:14. |
| APA | Zhong, Hua,Song, Yipeng,Hu, Shanliang,Zhang, Chengxu,&Li, Lili.(2025).Metagenomics-Metabolomics Reveals the Alleviation of Indole-3-Ethanol on Radiation-Induced Enteritis in Mice.JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY,35,14. |
| MLA | Zhong, Hua,et al."Metagenomics-Metabolomics Reveals the Alleviation of Indole-3-Ethanol on Radiation-Induced Enteritis in Mice".JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY 35(2025):14. |
入库方式： OAI收割
来源：烟台海岸带研究所
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