Gut microbiota and radiation-induced injury: mechanistic insights and microbial therapies
文献类型：期刊论文
| 作者 | Li, Lili3; Yang, Zian2,3; Yi, Yuetao3; Song, Yipeng1; Zhang, Wei3 |
| 刊名 | GUT MICROBES
 |
| 出版日期 | 2025-12-31 |
| 卷号 | 17期号:1页码:17 |
| 关键词 | Gut microbiota microbial metabolites radiotherapy novel strategies |
| ISSN号 | 1949-0976 |
| DOI | 10.1080/19490976.2025.2528429 |
| 通讯作者 | Song, Yipeng(syp1972@sina.com) ; Zhang, Wei(wei.zhang@flinders.edu.au) |
| 英文摘要 | Radiotherapy represents a crucial therapeutic modality in cancer treatment, yet its efficacy is frequently limited by radiation-induced toxicity. Growing evidence indicates that gut microbiota and their metabolites serve as key regulators of both radioprotective and radiosensitizing effects. This review systematically examines three fundamental regulatory mechanisms through which gut microbiota and its metabolites mitigate radiation-induced injury: (1) modulation of intestinal epithelial cell regeneration and tumor cell apoptosis via Wnt/beta-catenin and PI3K/AKT/mTOR pathways; (2) immunomodulation via Toll-like receptor activation and NF-kappa B signaling; (3) oxidative stress management via Nrf2 signaling. We also evaluate various microbiota-targeted interventions, ranging from probiotics and prebiotics to fecal microbiota transplantation and emerging engineered microbial therapies, highlighting their potential in clinical radiotherapy. Finally, we emphasize current limitations and future research directions, underscoring the need to overcome existing challenges in microbiome analysis and therapeutic durability to fully realize the potential of precision radio-microbiome medicine, which may provide valuable references for developing personalized radiotherapy strategies based on gut microbiota and their metabolites. |
| WOS关键词 | IONIZING-RADIATION ; CANCER ; PROTECTS ; TRANSPLANTATION ; EPITHELIUM ; PROBIOTICS ; INTESTINE ; CELLS |
| WOS研究方向 | Gastroenterology & Hepatology ; Microbiology |
| 语种 | 英语 |
| WOS记录号 | WOS:001523599200001 |
| 资助机构 | National Key Research and Development Program of China |
| 源URL | [http://ir.yic.ac.cn/handle/133337/41268]  |
| 专题 | 海岸带生物学与生物资源利用重点实验室 |
| 通讯作者 | Song, Yipeng; Zhang, Wei |
| 作者单位 | 1.Yantai Yuhuangding Hosp, Dept Radiotherapy, Yantai 264000, Peoples R China 2.Univ Chinese Acad Sci, Coll Marine Sci, Beijing, Peoples R China 3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Lili,Yang, Zian,Yi, Yuetao,et al. Gut microbiota and radiation-induced injury: mechanistic insights and microbial therapies[J]. GUT MICROBES,2025,17(1):17. |
| APA | Li, Lili,Yang, Zian,Yi, Yuetao,Song, Yipeng,&Zhang, Wei.(2025).Gut microbiota and radiation-induced injury: mechanistic insights and microbial therapies.GUT MICROBES,17(1),17. |
| MLA | Li, Lili,et al."Gut microbiota and radiation-induced injury: mechanistic insights and microbial therapies".GUT MICROBES 17.1(2025):17. |
入库方式： OAI收割
来源：烟台海岸带研究所
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