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Synthesis, Characterization, Antioxidant Activity, Antibacterial Activity, and Cytotoxicity of Quaternized Inulin Derivatives Bearing Aromatic Amides

文献类型：期刊论文

作者Chen, Yuan3; Mi, Yingqi1; Guo, Zhanyong2; Zhang, Hongwu3
刊名ANTIOXIDANTS
出版日期2025-09-06
卷号14期号:9页码:18
关键词antioxidant activity antibacterial activity cytotoxicity
DOI10.3390/antiox14091091
通讯作者Guo, Zhanyong(zhanyongguo@hotmail.com) ; Zhang, Hongwu(hwzhang@iue.ac.cn)
英文摘要In this study, a total of 12 new quaternized inulin (QIL) derivatives bearing aromatic amides were synthesized according to the ion exchange method. All the derivatives exhibited higher antioxidant activities in scavenging hydroxyl radicals, DPPH radicals, and superoxide radicals compared to pure inulin. Most of the derivatives could fully eliminate hydroxyl radicals at 1.6 mg/mL. Meanwhile, QIL derivatives exhibited increased antibacterial activity against Escherichia coli and Staphylococcus aureus compared to unmodified inulin. The structure-function relationship of the synthesized derivatives was discussed. Moreover, assays conducted with L929 cells (mouse fibroblasts) by the cell counting kit-8 (CCK-8) method did not show toxicities for the derivatives. Thus, the derivatives show promise for biomedical materials, functional foods, and pharmaceutical applications because they combine excellent antioxidant and antibacterial activities without exhibiting cytotoxicity.
WOS研究方向Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Food Science & Technology
语种英语
WOS记录号WOS:001579399900001
资助机构Natural Science Foundation of Shandong Province of China
源URL[http://ir.yic.ac.cn/handle/133337/41389]  
专题海岸带生物学与生物资源利用重点实验室
通讯作者Guo, Zhanyong; Zhang, Hongwu
作者单位1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
2.Jiangsu Ocean Univ, Sch Marine Sci & Fisheries, Lianyungang 222005, Peoples R China
3.Ludong Univ, Sch Mat Sci & Engn, Yantai 264025, Peoples R China
推荐引用方式
GB/T 7714		 Chen, Yuan,Mi, Yingqi,Guo, Zhanyong,et al. Synthesis, Characterization, Antioxidant Activity, Antibacterial Activity, and Cytotoxicity of Quaternized Inulin Derivatives Bearing Aromatic Amides[J]. ANTIOXIDANTS,2025,14(9):18.
APA Chen, Yuan,Mi, Yingqi,Guo, Zhanyong,&Zhang, Hongwu.(2025).Synthesis, Characterization, Antioxidant Activity, Antibacterial Activity, and Cytotoxicity of Quaternized Inulin Derivatives Bearing Aromatic Amides.ANTIOXIDANTS,14(9),18.
MLA Chen, Yuan,et al."Synthesis, Characterization, Antioxidant Activity, Antibacterial Activity, and Cytotoxicity of Quaternized Inulin Derivatives Bearing Aromatic Amides".ANTIOXIDANTS 14.9(2025):18.

入库方式： OAI收割

来源：烟台海岸带研究所

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