Structural analogs modulate olfactory and behavioral responses to a bile acid sex pheromone in sea lamprey (Petromyzon marinus)
文献类型：期刊论文
| 作者 | Scott, Anne M.1; Li, Ke1,2; Riedy, Joseph J.1,3; Li, Weiming1 |
| 刊名 | JOURNAL OF COMPARATIVE PHYSIOLOGY A-NEUROETHOLOGY SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY
 |
| 出版日期 | 2025-09-27 |
| 页码 | 13 |
| 关键词 | Olfaction Electrophysiology Structure-activity relationships Sensory ecology Chemoreception Behavioral antagonist |
| ISSN号 | 0340-7594 |
| DOI | 10.1007/s00359-025-01760-7 |
| 通讯作者 | Li, Weiming(liweim@msu.edu) |
| 英文摘要 | Male sea lamprey (Petromyzon marinus) release a sex pheromone featuring a potent bile acid 3-keto petromyzonol sulfate (3kPZS), which plays a critical role in attracting ovulated females to spawning sites during their terminal reproductive phase. In this study, we evaluated how systematic modifications of 3kPZS, referred to as the 11 analogs that retain the 3kPZS core structure with one or more functional group substitutions, affect female sea lamprey neurophysiological and behavioral responses to 3kPZS. Using electro-olfactogram recordings and two-choice flume behavioral assays, we characterized responses elicited by each analog and assessed whether the analogs interfered with 3kPZS-induced responses. Our results demonstrate that bile acid analogs with substitutions of hydroxyl or ketone groups with sulfate moieties at carbon positions 3, 7, 12, and 24 elicit distinct olfactory and behavioral responses in sea lamprey. Analogs with a sulfate group at the carbon-24 position tended to elicit potent olfactory responses of comparable magnitude to 3kPZS. Adding more sulfates at the carbon-3, 7, or 12 position altered behavioral valence and often neutralized or reversed female attraction to 3kPZS in a flume. These data elucidate structure-activity relationships and identify key structural determinants underlying sea lamprey olfactory detection and odorant-mediated behavioral responses. The findings may inform a potential approach for managing invasive sea lamprey populations in the Laurentian Great Lakes by disrupting bile acid mediated pheromone communication. Further research is needed to assess the utility of these compounds in natural stream environments and to refine the structural features of these pheromone antagonists to enhance their efficacy. |
| WOS关键词 | MIGRATORY PHEROMONE ; MOZAMBIQUE TILAPIA ; CHEMICAL CUES ; SENSITIVITY ; SALTS ; FISH ; RECEPTORS ; ECOLOGY ; SYSTEM ; TROUT |
| WOS研究方向 | Behavioral Sciences ; Neurosciences & Neurology ; Physiology ; Zoology |
| 语种 | 英语 |
| WOS记录号 | WOS:001581952400001 |
| 资助机构 | U.S. Fish and Wildlife Service and Fisheries and Oceans Canada ; U.S. Geological Survey Hammond Bay Biological Station - Great Lakes Fishery Commission |
| 源URL | [http://ir.yic.ac.cn/handle/133337/41395]  |
| 专题 | 海岸带生物学与生物资源利用重点实验室 |
| 通讯作者 | Li, Weiming |
| 作者单位 | 1.Michigan State Univ, Dept Fisheries & Wildlife, 480 Wilson Rd, E Lansing, MI 48824 USA 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Shandong, Peoples R China 3.Michigan State Univ, Biol Sci Program, 642 Red Cedar Rd 1110, E Lansing, MI 48824 USA |
| 推荐引用方式 GB/T 7714 | Scott, Anne M.,Li, Ke,Riedy, Joseph J.,et al. Structural analogs modulate olfactory and behavioral responses to a bile acid sex pheromone in sea lamprey (Petromyzon marinus)[J]. JOURNAL OF COMPARATIVE PHYSIOLOGY A-NEUROETHOLOGY SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY,2025:13. |
| APA | Scott, Anne M.,Li, Ke,Riedy, Joseph J.,&Li, Weiming.(2025).Structural analogs modulate olfactory and behavioral responses to a bile acid sex pheromone in sea lamprey (Petromyzon marinus).JOURNAL OF COMPARATIVE PHYSIOLOGY A-NEUROETHOLOGY SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY,13. |
| MLA | Scott, Anne M.,et al."Structural analogs modulate olfactory and behavioral responses to a bile acid sex pheromone in sea lamprey (Petromyzon marinus)".JOURNAL OF COMPARATIVE PHYSIOLOGY A-NEUROETHOLOGY SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY (2025):13. |
入库方式： OAI收割
来源：烟台海岸带研究所
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