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Acute hypoxia suppresses blood glycolysis in saker falcons (Falco cherrug) via NR3C1-mediated repression of HK1 Evidence from hematological and epigenomic profiling

文献类型：期刊论文

作者Wu, Wei3,4,5; Zhang, Xiao-Hang2,3,4,5; Du, Fei-Fei3,4,5; Gu, Zhong-Ru3,4,5; Hu, Li5,7; Chen, Jun-Feng4,5; Lin, Zhen-Zhen3,4,5; Pan, Sheng-Kai1,3,4,5; Zhan, Xiang-Jiang3,4,5,6
刊名ZOOLOGICAL RESEARCH
出版日期2025-09-17
卷号46期号:5页码:10
关键词Hypoxic response Qinghai-Xizang Plateau Saker falcons Glycolysis Climate change
ISSN号2095-8137
DOI10.24272/j.issn.2095-8137.2025.092
通讯作者Pan, Sheng-Kai(pansk@ioz.ac.cn) ; Zhan, Xiang-Jiang(zhanxj@ioz.ac.cn)
英文摘要Ongoing climate change is driving high-altitude bird species to occupy even higher elevations, yet physiological and regulatory responses enabling these transitions remain poorly understood. This study investigated acute hypoxic responses in saker falcons (Falco cherrug) inhabiting the Qinghai-Xizang Plateau by exposing individuals to simulated altitudes of 5 000-6 000 m above sea level (a.s.l.), exceeding their typical elevation range (approximately 4 300 m a.s.l.). GPS tracking data indicated that juvenile falcons maintained comparable activity levels across 4 000-5 000 m and 5 000-6 000 m a.s.l. ranges. However, pre-fledging individuals subjected to 6 000 m hypoxia for three days exhibited marked increases in hemoglobin concentration and blood glucose. Transcriptomic profiling revealed significant suppression of glycolytic activity, notably characterized by reduced expression of hexokinase 1 (HK1), a key enzymatic gene involved in the glycolytic pathway. ATAC-seq further identified enhanced chromatin accessibility within the HK1 locus under hypoxia, revealing two conserved cis-regulatory elements recognized by the transcription factor NR3C1 in the hypoxia-treated group. NR3C1 expression was negatively correlated with HK1. Notably, both elements were unique and evolutionarily conserved in avian taxa, suggesting a potential role in hypoxia resilience among highland birds. These findings provide mechanistic insights into the molecular and physiological strategies employed by sakers to tolerate acute hypoxic stress and inform conservation efforts for high-altitude bird species on the Qinghai-Xizang Plateau and other alpine ecosystems facing accelerating climate change.
WOS关键词DIFFERENTIAL EXPRESSION ; ENERGY-METABOLISM ; EVOLUTION ; ALIGNMENT ; TIBETAN ; GLUCOSE ; TRANSCRIPTOMES ; PERFORMANCE ; ADAPTATION ; TOLERANCE
WOS研究方向Zoology
语种英语
WOS记录号WOS:001586872700015
源URL[http://ir.yic.ac.cn/handle/133337/41450]  
专题海岸带生物学与生物资源利用重点实验室
通讯作者Pan, Sheng-Kai; Zhan, Xiang-Jiang
作者单位1.Beijing Forestry Univ, Sch Nat Conservat, Beijing 100083, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Cardiff Univ, Inst Zool Joint Lab Biocomplex Res, Beijing 100101, Peoples R China
4.Chinese Acad Sci, Inst Zool, Key Lab Anim Ecol & Conservat Biol, Beijing 100101, Peoples R China
5.Chinese Acad Sci, Inst Zool, State Key Lab Anim Biodivers Conservat & Integrate, Beijing 100101, Peoples R China
6.Chinese Acad Sci, Ctr Excellence Anim Evolut & Genet, Kunming 650201, Yunnan, Peoples R China
7.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Shandong, Peoples R China
推荐引用方式
GB/T 7714		 Wu, Wei,Zhang, Xiao-Hang,Du, Fei-Fei,et al. Acute hypoxia suppresses blood glycolysis in saker falcons (Falco cherrug) via NR3C1-mediated repression of HK1 Evidence from hematological and epigenomic profiling[J]. ZOOLOGICAL RESEARCH,2025,46(5):10.
APA Wu, Wei.,Zhang, Xiao-Hang.,Du, Fei-Fei.,Gu, Zhong-Ru.,Hu, Li.,...&Zhan, Xiang-Jiang.(2025).Acute hypoxia suppresses blood glycolysis in saker falcons (Falco cherrug) via NR3C1-mediated repression of HK1 Evidence from hematological and epigenomic profiling.ZOOLOGICAL RESEARCH,46(5),10.
MLA Wu, Wei,et al."Acute hypoxia suppresses blood glycolysis in saker falcons (Falco cherrug) via NR3C1-mediated repression of HK1 Evidence from hematological and epigenomic profiling".ZOOLOGICAL RESEARCH 46.5(2025):10.

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来源：烟台海岸带研究所

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