Amphibians as a source of bioactive antioxidant peptides: Emerging insights and therapeutic potential
文献类型：期刊论文
| 作者 | Zhu, Yi-Yun2,3,4,5; Zhao, Li-Mei1; Jia, Xin-Yi6; Liao, Guo-Jian3; Wang, Yi-Peng2,4,5 |
| 刊名 | ZOOLOGICAL RESEARCH
 |
| 出版日期 | 2025-09-17 |
| 卷号 | 46期号:5页码:25 |
| 关键词 | Antioxidant peptides (AOPs) Reactive oxygen species (ROS) Amphibians Skin photoaging Peptide drugs |
| ISSN号 | 2095-8137 |
| DOI | 10.24272/j.issn.2095-8137.2025.127 |
| 通讯作者 | Liao, Guo-Jian(gjliao@swu.edu.cn) ; Wang, Yi-Peng(ypwang@yic.ac.cn) |
| 英文摘要 | Oxidative stress arises from disruption of the balance between reactive oxygen species (ROS) production and detoxification and constitutes a fundamental driver of diverse pathological diseases. Skin photoaging is a well-recognized example, primarily driven by chronic ultraviolet (UV) exposure and marked by progressive structural and functional deterioration. UV-induced ROS accelerate macromolecular degradation and impair epidermal and dermal barrier integrity, highlighting the urgent need for effective antioxidant interventions. Antioxidant peptides (AOPs), whether naturally occurring or synthetically engineered, have shown considerable potential in mitigating ROS-induced cellular damage. Amphibians, which possess highly permeable skin and are continuously challenged by fluctuating environmental conditions, represent a rich source of bioactive peptides with potent antioxidant properties. In particular, AOPs isolated from amphibian skin secretions demonstrate notable efficacy in ROS scavenging and mitigation of oxidative damage, offering promising candidates for anti-photoaging therapies. This review provides an integrated overview of ROS generation and signaling, the molecular mechanisms linking oxidative stress to skin photoaging, and the emerging biomedical potential of amphibian-derived AOPs. Deeper mechanistic insight into their structure and function is expected to accelerate the development of novel peptide-based interventions for photoaging and other oxidative stress-associated dermatological disorders. |
| WOS关键词 | HOST-DEFENSE PEPTIDES ; HEALING-PROMOTING PEPTIDE ; OXIDATIVE STRESS ; ANTIMICROBIAL PEPTIDES ; ULTRAVIOLET-RADIATION ; TISSUE INHIBITOR ; SKIN SECRETIONS ; DNA-DAMAGE ; MATRIX METALLOPROTEINASES ; REDOX HOMEOSTASIS |
| WOS研究方向 | Zoology |
| 语种 | 英语 |
| WOS记录号 | WOS:001586872700019 |
| 资助机构 | National Natural Science Foundation of China ; Key Research & Development Plan in Social Development of Jiangsu Province ; Suzhou Agricultural Science and Technology Innovation Project |
| 源URL | [http://ir.yic.ac.cn/handle/133337/41456]  |
| 专题 | 海岸带生物学与生物资源利用重点实验室 |
| 通讯作者 | Liao, Guo-Jian; Wang, Yi-Peng |
| 作者单位 | 1.Soochow Univ, Suzhou Med Coll, Sch Basic Med Sci, Dept Pathol & Pathophysiol, Suzhou 215123, Jiangsu, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Shandong, Peoples R China 3.Southwest Univ, Med Res Inst, Coll Pharmaceut Sci, Chongqing 400715, Peoples R China 4.Soochow Univ, Coll Pharmaceut Sci, Dept Biopharmaceut Sci, Suzhou 215123, Jiangsu, Peoples R China 5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 6.Natl Univ Singapore, Food Sci & Technol Ctr, Dept Food Sci & Technol, Singapore 119077, Singapore |
| 推荐引用方式 GB/T 7714 | Zhu, Yi-Yun,Zhao, Li-Mei,Jia, Xin-Yi,et al. Amphibians as a source of bioactive antioxidant peptides: Emerging insights and therapeutic potential[J]. ZOOLOGICAL RESEARCH,2025,46(5):25. |
| APA | Zhu, Yi-Yun,Zhao, Li-Mei,Jia, Xin-Yi,Liao, Guo-Jian,&Wang, Yi-Peng.(2025).Amphibians as a source of bioactive antioxidant peptides: Emerging insights and therapeutic potential.ZOOLOGICAL RESEARCH,46(5),25. |
| MLA | Zhu, Yi-Yun,et al."Amphibians as a source of bioactive antioxidant peptides: Emerging insights and therapeutic potential".ZOOLOGICAL RESEARCH 46.5(2025):25. |
入库方式： OAI收割
来源：烟台海岸带研究所
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