Precisely Targeting Cardiac Remodeling Nanomachine for Restarting Healthy Heartbeat
文献类型：期刊论文
| 作者 | Wang, Weixin4,5,6; Gao, Rui5; Zhang, Lin5; Dong, Yu5; Du, Yongsheng5; Dai, Qian7; Liu, Baolong8,9; Fang, Chunyan10; Wang, Chuanle1; Sun, Hao2 |
| 刊名 | ADVANCED HEALTHCARE MATERIALS
 |
| 出版日期 | 2025-10-08 |
| 页码 | 14 |
| 关键词 | atrial fibrillation cardiac remodeling star arrow-separated nanomachines Zn2+/Mg2+/H-2 release |
| ISSN号 | 2192-2640 |
| DOI | 10.1002/adhm.202503478 |
| 通讯作者 | Sun, Hao(hao.sun@ucl.ac.uk) ; Tong, Fei(tongxuchang@163.com) ; Huang, Wei(iamwhuang@nwpu.edu.cn) |
| 英文摘要 | Atrial fibrillation (AF) is a common arrhythmia that can cause serious symptoms and affect the quality of life of patients. Therefore, the treatment of AF has always faced challenges in the medical field. Here, Zn@Mg@MSNs@PEG nanosphere-based nanomachines with a unique composite structure in which Zn and Mg are deposited on the surface of mesoporous silica nanoparticle (MSNs) nanospheres, followed by polyethylene glycol (PEG) modification, display excellent acid-responsive properties due to their unique ion sputtering structure. The nanomaterials show autonomous mobility in PBS with acid input, without the use of energetic toxic fuels. This active release of Zn2+/Mg2+/H-2 improves the intracellular Ca2+/Na+/K+/Cl- ratio via nanomachines. The intracellular Ca2+/Na+/K+/Cl- gradients are the key to AF electrophysiology. Electrophysiology amelioration combined with oxidative stress and inflammatory mediator inhibition is found to mediate AF following Zn@Mg@MSNs@PEG nanomachine invasion. The designed star arrow-separated nanomachine system, activated by acidic conditions to enhance mobility and enable the targeted release of Zn-2(+), Mg-2(+), and H-2, effectively inhibits cardiac remodeling associated with AF by precisely targeting both structural and electrical abnormalities, achieving therapeutic effects without causing additional damage. |
| WOS关键词 | ATRIAL-FIBRILLATION ; CALCIUM LEAK ; RECEPTOR ; CHANNELS ; I-K,I-ACH ; SODIUM ; MECHANISMS ; INHIBITION ; ARRHYTHMIA ; MAGNESIUM |
| WOS研究方向 | Engineering ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001589746000001 |
| 资助机构 | National Scholarship Council of the Ministry of Education of China |
| 源URL | [http://ir.yic.ac.cn/handle/133337/41462]  |
| 专题 | 烟台海岸带研究所_中科院烟台海岸带研究所知识产出 |
| 通讯作者 | Sun, Hao; Tong, Fei; Huang, Wei |
| 作者单位 | 1.Guangzhou Med Univ, State Key Lab Resp Dis, Guangzhou 511436, Peoples R China 2.UCL, UCL Div Med, Gower St, London WC1E 6BT, England 3.Northwestern Polytchn Univ, Inst Flexible Elect IFE, Natl Key Lab Flexible Elect, Xian 710072, Peoples R China 4.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Shandong, Peoples R China 5.Binzhou Med Univ, Sch Pharm, Dept Pharmacol, Yantai 264003, Peoples R China 6.Shandong Univ Tradit Chinese Med, Qingdao Acad Chinese Med Sci, Qingdao 266112, Peoples R China 7.Army Mil Med Univ, Xinqiao Hosp, Clin Med Res Ctr, Chongqing 400038, Peoples R China 8.China Med Univ, Dept Dev Cell Biol, Key Lab Cell Biol, Minist Publ Hlth, R China, Shenyang 110122, Peoples R China 9.China Med Univ, Key Lab Med Cell Biol, Minist Educ, Shenyang 110122, Peoples R China 10.Sichuan Acad Agr Sci, Inst Qual Stand & Testing Technol Agroprod, Chengdu 637000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Weixin,Gao, Rui,Zhang, Lin,et al. Precisely Targeting Cardiac Remodeling Nanomachine for Restarting Healthy Heartbeat[J]. ADVANCED HEALTHCARE MATERIALS,2025:14. |
| APA | Wang, Weixin.,Gao, Rui.,Zhang, Lin.,Dong, Yu.,Du, Yongsheng.,...&Huang, Wei.(2025).Precisely Targeting Cardiac Remodeling Nanomachine for Restarting Healthy Heartbeat.ADVANCED HEALTHCARE MATERIALS,14. |
| MLA | Wang, Weixin,et al."Precisely Targeting Cardiac Remodeling Nanomachine for Restarting Healthy Heartbeat".ADVANCED HEALTHCARE MATERIALS (2025):14. |
入库方式： OAI收割
来源：烟台海岸带研究所
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