Unveiling Subthreshold Hormesis of Antibiotics in Global Waters
文献类型：期刊论文
| 作者 | Sun, Tao1,2; Wu, Huifeng1,3; Ji, Chenglong1,3; Shan, Xiujuan3; Li, Fei1 |
| 刊名 | ENVIRONMENTAL SCIENCE & TECHNOLOGY
 |
| 出版日期 | 2025-10-21 |
| 卷号 | 59期号:41页码:22212-22226 |
| 关键词 | antibiotics low-dose stimulation ecologicalrisk assessment subthreshold effect safety margin |
| ISSN号 | 0013-936X |
| DOI | 10.1021/acs.est.5c09003 |
| 通讯作者 | Wu, Huifeng(hfwu@yic.ac.cn) ; Li, Fei(fli@yic.ac.cn) |
| 英文摘要 | Low-dose antibiotics may pose ecological risk by inducing hormesis, an emerging concern largely overlooked by ecological risk assessment (ERA) guidelines worldwide. This study compiled data sets on antibiotic-induced hormesis and water concentrations to integrate hormesis into the ERA of antibiotics and explore its global implications. A hormesis data set comprising 3,149 dose-response observations was gathered, covering 57 antibiotics and 72 aquatic species. The standardized hormetic amplitudes followed a three-parameter log-normal distribution and were mainly driven by the species tested. Further comparison revealed overlaps between hormesis-triggered doses and predicted no-effect concentrations (PNECs), highlighting the unrecognized subthreshold effects. Promisingly, a pathway for incorporating hormesis into ERA was proposed, introducing two hormesis-based risk thresholds, the predicted no-stimulation concentration (PNSC) and the predicted no-inhibition concentration (PNIC). Realistically, 89,612 antibiotic records were identified in global waters for compounds inducing hormesis, with 8% reaching the lowest induction doses. Global risk assessment indicated that antibiotic concentrations were generally below the conventional PNEC, while regions exceeding the PNSC and PNIC were widespread, with the spatial distribution of risk areas expanded under more stringent assessment factors. Collectively, the integration of hormesis into ERA enhances the characterization of subthreshold risks and facilitates the detection of early warning signals from low-dose antibiotic contamination. |
| WOS关键词 | EMERGING CONTAMINANTS ; METAANALYSIS |
| WOS研究方向 | Engineering ; Environmental Sciences & Ecology |
| 语种 | 英语 |
| WOS记录号 | WOS:001591464600001 |
| 资助机构 | National Natural Science Foundation of China ; National Natural Science Foundation of China ; Taishan Scholars Program ; Shandong Provincial Natural Science Foundation ; Yantai Special Supporting Funds for Leading Talents above Provincial |
| 源URL | [http://ir.yic.ac.cn/handle/133337/41474]  |
| 专题 | 烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室 |
| 通讯作者 | Wu, Huifeng; Li, Fei |
| 作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Shandong Key Lab Coastal Environm Proc, Yantai 264003, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Qingdao Marine Sci & Technol Ctr, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266237, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Tao,Wu, Huifeng,Ji, Chenglong,et al. Unveiling Subthreshold Hormesis of Antibiotics in Global Waters[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2025,59(41):22212-22226. |
| APA | Sun, Tao,Wu, Huifeng,Ji, Chenglong,Shan, Xiujuan,&Li, Fei.(2025).Unveiling Subthreshold Hormesis of Antibiotics in Global Waters.ENVIRONMENTAL SCIENCE & TECHNOLOGY,59(41),22212-22226. |
| MLA | Sun, Tao,et al."Unveiling Subthreshold Hormesis of Antibiotics in Global Waters".ENVIRONMENTAL SCIENCE & TECHNOLOGY 59.41(2025):22212-22226. |
入库方式： OAI收割
来源：烟台海岸带研究所
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