Reactive oxygen species activatable nanotherapeutics for evaluating and relieving nanoplastics-induced oxidative stress
文献类型：期刊论文
| 作者 | Fu, Lili1; Huang, Yan3; Sun, Xiao3; Wang, Xinlei3; Li, Shuang3; Wang, Xiaoyan3; Kang, Qi1; Shen, Dazhong1; Chen, Lingxin2,3,4 |
| 刊名 | CHEMICAL ENGINEERING JOURNAL
 |
| 出版日期 | 2025-11-15 |
| 卷号 | 524页码:12 |
| 关键词 | Nanoplastics Oxidative stress Liposomes Fluorescence imaging |
| ISSN号 | 1385-8947 |
| DOI | 10.1016/j.cej.2025.169081 |
| 通讯作者 | Huang, Yan(yhuang@bzmc.edu.cn) ; Wang, Xiaoyan(kangqi@sdnu.edu.cn) ; Shen, Dazhong(dzshen@sdnu.edu.cn) ; Chen, Lingxin(lxchen@yic.ac.cn) |
| 英文摘要 | Nanoplastics are a common airborne pollutant and are highly susceptible to biological oxidative stress. However, effective assessment methods and treatment strategies are still lacking. Herein, we prepared reactive oxygen species (ROS)-responsive nanocarriers (PTS) by self-assembling poly (ethylene glycol) (PEG) and stearylamine (C18) via ROS-sensitive thione linkers (TL). These nanocarriers were co-loaded with near-infrared fluorescent groups (heptamethylindocyanine, Cy) and hydrogen sulfide (H2S) donor drugs (diallyl trisulfide, DT). The purpose was to evaluate and mitigate the oxidative stress caused by nanoplastics. We successfully realized the detection of polystyrene nanoplastics-induced increase of ROS in organisms by PTS-CyDT. The findings suggest that nanoplastics-induced biological oxidative stress may be related to various pathways such as mitogenactivated protein kinase (MAPK). Importantly, H2S produced by DT was able to alleviate nanoplastics-induced biooxidative stress by upregulating the Kelch-like ECH-associated protein 1 (Keap1)-nuclear factor-E2-related factor (Nrf2) pathway and its downstream proteins. This work innovatively integrates ROS-responsive links, fluorescent molecules, and H2S donor drugs into a single nanoplatform for the first time. The results indicate that the ROS-sensitive PTS-CyDT could potentially serve as a promising and innovative nanoplatform for evaluating and relieving oxidative stress induced by nanoplastics in organisms. |
| WOS研究方向 | Engineering |
| 语种 | 英语 |
| WOS记录号 | WOS:001589337700028 |
| 资助机构 | National Natural Science Foundation of China ; Research Initiation Fund of Binzhou Medical University ; Taishan Scholar Project Special Funding |
| 源URL | [http://ir.yic.ac.cn/handle/133337/41477]  |
| 专题 | 烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室 |
| 通讯作者 | Huang, Yan; Wang, Xiaoyan; Shen, Dazhong; Chen, Lingxin |
| 作者单位 | 1.Shandong Normal Univ, Coll Chem Chem Engn & Mat Sci, Jinan 250014, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Shandong Key Lab Coastal Environm Proc,Res Ctr Coa, Yantai 264003, Peoples R China 3.Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China 4.Shaoxing Univ, Coll Chem & Chem Engn, Shaoxing 312000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fu, Lili,Huang, Yan,Sun, Xiao,et al. Reactive oxygen species activatable nanotherapeutics for evaluating and relieving nanoplastics-induced oxidative stress[J]. CHEMICAL ENGINEERING JOURNAL,2025,524:12. |
| APA | Fu, Lili.,Huang, Yan.,Sun, Xiao.,Wang, Xinlei.,Li, Shuang.,...&Chen, Lingxin.(2025).Reactive oxygen species activatable nanotherapeutics for evaluating and relieving nanoplastics-induced oxidative stress.CHEMICAL ENGINEERING JOURNAL,524,12. |
| MLA | Fu, Lili,et al."Reactive oxygen species activatable nanotherapeutics for evaluating and relieving nanoplastics-induced oxidative stress".CHEMICAL ENGINEERING JOURNAL 524(2025):12. |
入库方式： OAI收割
来源：烟台海岸带研究所
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