Arctigenin from Saussurea medusa Maxim. Targets the PI3K/AKT Pathway to Inhibit Hepatocellular Carcinoma Proliferation and Induces Apoptosis
文献类型：期刊论文
| 作者 | Yu, Ruitao; Chen, Jinghua; Yu, Ruixue |
| 刊名 | NUTRIENTS
 |
| 出版日期 | 2025 |
| 卷号 | 17期号:19 |
| 关键词 | arctigenin hepatocellular carcinoma PI3K/AKT pathway network pharmacology Tibetan medicine apoptosis |
| 英文摘要 | Background: Hepatocellular carcinoma (HCC) is a highly lethal malignancy with limited therapeutic options. Arctigenin (ARC), a natural lignan derived from Saussurea medusa, exhibits anti-cancer activity, but its mechanism against HCC remain incompletely elucidated. Methods: This study integrated network pharmacology, molecular docking, molecular dynamics, in vitro, and in vivo experiments to investigate ARC's anti-HCC effects. Results: Seventy-five potential targets shared between ARC and HCC were identified, with KEGG analysis highlighting the PI3K/AKT pathway as central. ARC showed strong binding to key proteins, and molecular dynamics indicated stable interactions with PIK3CA and GSK3B. In HepG2 cells, ARC inhibited proliferation in a dose- and time-dependent manner (IC50: 11.17 mu M at 24 h, 4.888 mu M at 48 h), induced apoptosis at high concentrations, suppressed PIK3CA phosphorylation, and increased GSK3B (Ser9) phosphorylation. In H22 tumor-bearing mice, ARC dose-dependently inhibited tumor growth (high dose: 50.6% vs. 63.0% for CTX) with minimal weight loss. Conclusions: These findings suggest ARC suppresses HCC by modulating the PI3K/AKT pathway, providing evidence for its development as a plant-derived therapeutic agent. |
| 源URL | [http://210.75.249.4/handle/363003/62348]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 推荐引用方式 GB/T 7714 | Yu, Ruitao,Chen, Jinghua,Yu, Ruixue. Arctigenin from Saussurea medusa Maxim. Targets the PI3K/AKT Pathway to Inhibit Hepatocellular Carcinoma Proliferation and Induces Apoptosis[J]. NUTRIENTS,2025,17(19). |
| APA | Yu, Ruitao,Chen, Jinghua,&Yu, Ruixue.(2025).Arctigenin from Saussurea medusa Maxim. Targets the PI3K/AKT Pathway to Inhibit Hepatocellular Carcinoma Proliferation and Induces Apoptosis.NUTRIENTS,17(19). |
| MLA | Yu, Ruitao,et al."Arctigenin from Saussurea medusa Maxim. Targets the PI3K/AKT Pathway to Inhibit Hepatocellular Carcinoma Proliferation and Induces Apoptosis".NUTRIENTS 17.19(2025). |
入库方式： OAI收割
来源：西北高原生物研究所
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