The Neuroprotective Effects of Cyanidin Derivatives on AlCl3-Induced Zebrafish Model of Alzheimer's Disease
文献类型：期刊论文
| 作者 | Wu, Yun; Gao, Yidan; Tie, Fangfang; Wang, Ruinan; Hu, Na; Dong, Qi; Fu, Chunxiang; Wang, Honglun |
| 刊名 | MOLECULES
 |
| 出版日期 | 2025 |
| 卷号 | 30期号:18 |
| 关键词 | Alzheimer's disease acetylcholinesterase aluminum cyanidin molecular docking zebrafish |
| 英文摘要 | Alzheimer's disease (AD) is characterized by cholinergic deficits and neuronal damage, making acetylcholinesterase (AChE) a crucial therapeutic target. Cyanidin derivatives, sourced from the diet as anthocyanins, exhibit neuroprotective properties, yet comparative investigations are scarce. This research explored the neuroprotective impacts of five cyanidin derivatives, namely cyanidin-3-O-(trans-p-coumaroyl)-diglycoside (C3GG), cyanidin-3-O-rutinoside (C3R), cyanidin-3-O-arabinoside (C3A), cyanidin-3-O-sophoroside (C3S), and cyanidin-3-O-xyloside (C3X), utilizing an aluminum-chloride (AlCl3)-induced zebrafish model of AD. The administration of these compounds ameliorated zebrafish locomotor impairments, suppressed AChE activity, decreased brain oxidative stress levels, upregulated AD-related gene expression, and mitigated brain tissue pathological changes. Molecular docking and dynamics simulations indicated that cyanidin derivatives exhibit robust binding affinity and stable binding to AChE. Particularly, C3R demonstrated the most potent multi-faceted neuroprotective effects among the tested derivatives, suggesting its potential as a promising lead compound for AD therapy. |
| 源URL | [http://210.75.249.4/handle/363003/62371]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 推荐引用方式 GB/T 7714 | Wu, Yun,Gao, Yidan,Tie, Fangfang,et al. The Neuroprotective Effects of Cyanidin Derivatives on AlCl3-Induced Zebrafish Model of Alzheimer's Disease[J]. MOLECULES,2025,30(18). |
| APA | Wu, Yun.,Gao, Yidan.,Tie, Fangfang.,Wang, Ruinan.,Hu, Na.,...&Wang, Honglun.(2025).The Neuroprotective Effects of Cyanidin Derivatives on AlCl3-Induced Zebrafish Model of Alzheimer's Disease.MOLECULES,30(18). |
| MLA | Wu, Yun,et al."The Neuroprotective Effects of Cyanidin Derivatives on AlCl3-Induced Zebrafish Model of Alzheimer's Disease".MOLECULES 30.18(2025). |
入库方式： OAI收割
来源：西北高原生物研究所
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