Aplf/Dna2 variants drive chromosomal fission and accelerate speciation in zokors
文献类型：期刊论文
| 作者 | Wan, Na; Duan, Qijiao; Cai, Zhenyuan; Zhu, Zhanwu; Wang, JingOu; Tian, Yonghui; Shen, Wei; Li, Bowen; Kuang, Zhuoran; Liang, Xiaolong |
| 刊名 | SCIENCE ADVANCES
 |
| 出版日期 | 2025 |
| 卷号 | 11期号:36 |
| 英文摘要 | Chromosomal fissions and fusions are common, yet the molecular mechanisms and implications in speciation remain poorly understood. Here, we confirm a fission event in one zokor species through multiple-omics and functional analyses. We traced this event to a mutation in a splicing enhancer of the DNA repair gene Aplf in the fission-bearing species, which caused exon skipping and produced a truncated protein that disrupted DNA repair. An intronic deletion in Dna2, known to facilitate neo-telomere formation when knocked out, reduced gene activity. These variants collectively drove chromosomal fission in this zokor species. The newly formed chromosome became fixed due to carrying essential genes and strong selective pressure. While geographic isolation likely initiated the divergence of this species and the sister one, the fission event and associated decline at the chromosome level in gene flow probably exacerbated the speciation process. Our work elucidates the genetic basis of chromosomal fission and underscores its role in speciation dynamics. |
| 源URL | [http://210.75.249.4/handle/363003/62373]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 推荐引用方式 GB/T 7714 | Wan, Na,Duan, Qijiao,Cai, Zhenyuan,et al. Aplf/Dna2 variants drive chromosomal fission and accelerate speciation in zokors[J]. SCIENCE ADVANCES,2025,11(36). |
| APA | Wan, Na.,Duan, Qijiao.,Cai, Zhenyuan.,Zhu, Zhanwu.,Wang, JingOu.,...&Li, Kexin.(2025).Aplf/Dna2 variants drive chromosomal fission and accelerate speciation in zokors.SCIENCE ADVANCES,11(36). |
| MLA | Wan, Na,et al."Aplf/Dna2 variants drive chromosomal fission and accelerate speciation in zokors".SCIENCE ADVANCES 11.36(2025). |
入库方式： OAI收割
来源：西北高原生物研究所
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