Genome-wide selective sweep analysis of plateau-type Tibetan and Zhashijia Sheep: Insights into adaptation, growth, and meat production traits
文献类型：期刊论文
| 作者 | Liu, Dehui; Li, Xue; Zhao, Jincai; Wang, Lei; Pei, Quanbang; Sun, De; Ren, Qianben; Bao, Guoxiang; Han, Buying; Zhang, Wenkui |
| 刊名 | SMALL RUMINANT RESEARCH
 |
| 出版日期 | 2025 |
| 卷号 | 252 |
| 关键词 | Genome-wide association High-altitude adaptation Selective sweep Candidate genes Plateau-type Tibetan sheep Zhashijia sheep |
| 英文摘要 | Qinghai is renowned as China's capital of Tibetan sheep, with plateau-type Tibetan sheep and Zhashijia sheep being exceptional breeds in the province. However, limited knowledge exists regarding the genetic characteristics or variations underlying their economically essential traits. Therefore, the present study was carried out on plateau-type Tibetan and Zhashijia sheep and aimed to identify the candidate genes regulating the differences in production performance between them by genome-wide selective sweep analysis and, ultimately, by combined analyses of two methods (Fst and Pi, Pi and Tajima's D). This study identified genes associated with plateau acclimatization, growth and development, body size, and meat quality through Fst, Pi, and Tajima's D. These genes include HBB, HBE1, GPX1, the HOX gene family, SIRT3, MRAP2, MMAB, BMP4, NCAM2, PCCA, MRPS6, P4HTM, and PLAAT3. Enrichment analyses indicated significant enrichment in key pathways, including amino sugar and nucleotide sugar metabolism, arachidonic acid metabolism, Carbon metabolism, and ribosome function. The findings provided valuable insights for breeding programs to improve growth performance in Tibetan sheep. |
| 源URL | [http://210.75.249.4/handle/363003/62392]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 推荐引用方式 GB/T 7714 | Liu, Dehui,Li, Xue,Zhao, Jincai,et al. Genome-wide selective sweep analysis of plateau-type Tibetan and Zhashijia Sheep: Insights into adaptation, growth, and meat production traits[J]. SMALL RUMINANT RESEARCH,2025,252. |
| APA | Liu, Dehui.,Li, Xue.,Zhao, Jincai.,Wang, Lei.,Pei, Quanbang.,...&Tian, Dehong.(2025).Genome-wide selective sweep analysis of plateau-type Tibetan and Zhashijia Sheep: Insights into adaptation, growth, and meat production traits.SMALL RUMINANT RESEARCH,252. |
| MLA | Liu, Dehui,et al."Genome-wide selective sweep analysis of plateau-type Tibetan and Zhashijia Sheep: Insights into adaptation, growth, and meat production traits".SMALL RUMINANT RESEARCH 252(2025). |
入库方式： OAI收割
来源：西北高原生物研究所
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