Flavone C-Glycosides from Dianthus superbus L. Attenuate Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) via Multi-Pathway Regulations
文献类型：期刊论文
| 作者 | Chu, Ming; Tong, Yingying; Zhang, Lei; Zhang, Yu; Dang, Jun; Li, Gang |
| 刊名 | NUTRIENTS
 |
| 出版日期 | 2025 |
| 卷号 | 17期号:15 |
| 关键词 | MASLD Dianthus superbus L. flavone C-glycosides lipid metabolism insulin resistance inflammation apoptosis |
| 英文摘要 | Background: The metabolic dysfunction-associated steatotic liver disease (MASLD) represents an escalating global health concern, with effective treatments still lacking. Given its complex pathogenesis, multi-targeted strategies are highly desirable. Methods: This study reports the isolation of four flavone C-glycosides (FCGs) from Dianthus superbus L. and explores their potential in treating MASLD. The bioactivity and underlying mechanisms of FCGs were systematically evaluated by integrating network pharmacology, molecular docking, and zebrafish model validation. Results: Network pharmacology analysis revealed that FCGs may modulate multiple MASLD-related pathways, including lipid metabolism, insulin signaling, inflammation, and apoptosis. Molecular docking further confirmed strong binding affinities between FCGs and key protein targets involved in these pathways. In the zebrafish model of MASLD induced by egg yolk powder, FCGs administration markedly attenuated obesity, hepatic lipid accumulation, and liver tissue damage. Furthermore, FCGs improved lipid metabolism and restored locomotor function. Molecular analyses confirmed that FCGs upregulated PPAR gamma expression to promote lipid metabolism, restored insulin signaling by enhancing INSR, PI3K, and AKT expression, and suppressed inflammation by downregulating TNF, IL-6 and NF-kappa B. Additionally, FCGs inhibited hepatocyte apoptosis by elevating the BCL-2/BAX ratio. Conclusions: These findings highlight the multi-pathway regulatory effects of FCGs in MASLD, underscoring its potential as a novel therapeutic candidate for further preclinical development. |
| 源URL | [http://210.75.249.4/handle/363003/62398]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 推荐引用方式 GB/T 7714 | Chu, Ming,Tong, Yingying,Zhang, Lei,et al. Flavone C-Glycosides from Dianthus superbus L. Attenuate Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) via Multi-Pathway Regulations[J]. NUTRIENTS,2025,17(15). |
| APA | Chu, Ming,Tong, Yingying,Zhang, Lei,Zhang, Yu,Dang, Jun,&Li, Gang.(2025).Flavone C-Glycosides from Dianthus superbus L. Attenuate Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) via Multi-Pathway Regulations.NUTRIENTS,17(15). |
| MLA | Chu, Ming,et al."Flavone C-Glycosides from Dianthus superbus L. Attenuate Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) via Multi-Pathway Regulations".NUTRIENTS 17.15(2025). |
入库方式： OAI收割
来源：西北高原生物研究所
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