Plateau Environment, Gut Microbiota, and Depression: A Possible Concealed Connection?
文献类型：期刊论文
| 作者 | Qiao, Yajun; Cheng, Ruiying; Li, Xiaohui; Zheng, Huimin; Guo, Juan; Wei, Lixin; Gao, Tingting; Bi, Hongtao |
| 刊名 | CURRENT ISSUES IN MOLECULAR BIOLOGY
 |
| 出版日期 | 2025 |
| 卷号 | 47期号:7 |
| 关键词 | plateau environment depression gut microbiota brain-gut axis |
| 英文摘要 | Plateau environments present unique mental health challenges owing to stressors including hypoxia, low temperatures, and intense ultraviolet (UV) radiation. These factors induce structural and functional alterations in the gut microbiota, disrupting gut-brain axis homeostasis and contributing to the higher prevalence of depression in plateau regions relative to flatland areas. For example, studies report that 28.6% of Tibetan adults and 29.2% of children/adolescents on the Qinghai-Tibet Plateau experience depression, with increasing evidence linking this trend to alterations in the gut microbiota. Dysbiosis contributes to depression through three interconnected mechanisms: (1) Neurotransmitter imbalance: Reduced bacterial diversity impairs serotonin synthesis, disrupting emotional regulation. (2) Immune dysregulation: Compromised gut barrier function allows bacterial metabolites to trigger systemic inflammation via toll-like receptor signaling pathways. (3) Metabolic dysfunction: Decreased short-chain fatty acid levels weaken neuroprotection and exacerbate hypothalamic-pituitary-adrenal axis stress responses. Current interventions-including dietary fiber, probiotics, and fecal microbiota transplantation-aim to restore microbiota balance and increase short-chain fatty acids, alleviating depressive symptoms. However, key knowledge gaps remain in understanding the underlying mechanisms and generating population-specific data. In conclusion, existing evidence indicates an association between plateau environments, the gut microbiota, and depression, but causal relationships and underlying mechanisms require further empirical investigation. Integrating multiomics technologies to systematically explore interactions among high-altitude environments, the microbiota and the brain will facilitate the development of precision therapies such as personalized nutrition and tailored probiotics to protect mental health in high-altitude populations. |
| 源URL | [http://210.75.249.4/handle/363003/62417]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 推荐引用方式 GB/T 7714 | Qiao, Yajun,Cheng, Ruiying,Li, Xiaohui,et al. Plateau Environment, Gut Microbiota, and Depression: A Possible Concealed Connection?[J]. CURRENT ISSUES IN MOLECULAR BIOLOGY,2025,47(7). |
| APA | Qiao, Yajun.,Cheng, Ruiying.,Li, Xiaohui.,Zheng, Huimin.,Guo, Juan.,...&Bi, Hongtao.(2025).Plateau Environment, Gut Microbiota, and Depression: A Possible Concealed Connection?.CURRENT ISSUES IN MOLECULAR BIOLOGY,47(7). |
| MLA | Qiao, Yajun,et al."Plateau Environment, Gut Microbiota, and Depression: A Possible Concealed Connection?".CURRENT ISSUES IN MOLECULAR BIOLOGY 47.7(2025). |
入库方式： OAI收割
来源：西北高原生物研究所
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