Comparative macrogenomics reveal plateau adaptation of gut microbiome in cervids
文献类型：期刊论文
| 作者 | Li, Bin; Yang, Yuangang; Xu, Bo; Song, Pengfei; Jiang, Feng; Gao, Hongmei; Cai, Zhenyuan; Gu, Haifeng; Zhang, Tongzuo |
| 刊名 | BMC BIOLOGY
 |
| 出版日期 | 2025 |
| 卷号 | 23期号:1 |
| 关键词 | Cervids Metagenome-assembled genomes Comparative macrogenomics Structural variation Plateau adaptation |
| 英文摘要 | BackgroundDiverse gut microbiota in animals significantly influences host physiology, ecological adaptation, and evolution. However, the specific functional roles of gut microbiota in facilitating host adaptation, as well as the coevolutionary dynamics between microbiota and their hosts, remain largely understudied.ResultsA total of 41,847 metagenome-assembled genomes and 3193 high-quality species-level genome bins were generated, establishing a comprehensive gut microbiome catalog for cervids in this study. Phylogenetic analysis revealed a coevolutionary relationship between cervids and their gut microbiota. Comparative metagenomic analyses further indicated that the gut microbiota of plateau cervids have undergone genome-level adaptations related to energy metabolism. At the genus level, species-level genome bins from the genera Alistipes and Faecousia in plateau cervids exhibit enhanced energy metabolism capabilities. Structural variations analysis revealed that the insertion and duplications structural variations in the gut microbiota of plateau cervids were significantly enriched in energy metabolism pathways. In contrast, the deletions and contractions in structural variations were predominantly enriched with metabolic pathways involved in the biosynthesis of diverse biochemical molecules.ConclusionsOur study provides a comprehensive gut microbiome catalog of the cervid gut microbiota, revealing the coevolutionary relationship between cervid gut microbiota and hosts. These findings highlight the adaptive genomic evolution of the gut microbiota in contributing to the plateau adaptability of cervids and offer new insights into the mechanisms by which the gut microbiota help hosts adapt to extreme environments. |
| 源URL | [http://210.75.249.4/handle/363003/62427]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 推荐引用方式 GB/T 7714 | Li, Bin,Yang, Yuangang,Xu, Bo,et al. Comparative macrogenomics reveal plateau adaptation of gut microbiome in cervids[J]. BMC BIOLOGY,2025,23(1). |
| APA | Li, Bin.,Yang, Yuangang.,Xu, Bo.,Song, Pengfei.,Jiang, Feng.,...&Zhang, Tongzuo.(2025).Comparative macrogenomics reveal plateau adaptation of gut microbiome in cervids.BMC BIOLOGY,23(1). |
| MLA | Li, Bin,et al."Comparative macrogenomics reveal plateau adaptation of gut microbiome in cervids".BMC BIOLOGY 23.1(2025). |
入库方式： OAI收割
来源：西北高原生物研究所
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