Chromosome-level genome of Neodon fuscus sheds light on the evolution and plateau adaptation of N. fuscus and Neodon
文献类型：期刊论文
| 作者 | Yang, Peng; Qu, Jiapeng; Wang, Yingxu; Xu, Zhongshi; Feng, Tuo; Chang, Gang; Xu, Lulu; Dong, Rong; Mi, Da; Ren, Yandong |
| 刊名 | BMC GENOMICS
 |
| 出版日期 | 2025 |
| 卷号 | 26期号:1 |
| 关键词 | High-altitude adaptation Reference-quality genome Comparative genomics Neodon |
| 英文摘要 | BackgroundNeodon, a typical group of high-altitude rodents, originated in the high-altitude regions of the Tibet-Himalayan area. These rodents inhabit meadows, swampy grasslands, and shrublands at elevations ranging from 3,700 to 4,800 m in Qinghai-Tibet Plateau, where they experience environment stresses such as hypoxia, enhanced ultraviolet radiation, and low temperature.ResultsIn this study, we assembled a high-quality chromosome-level genome of Neodon fuscus and use it to investigate the potential genetic bases of high-altitude adaptation. The genome of N. fuscus shows gene family expansion in genes related to immunity. Comparative genomics analysis revealed several positively selected genes and rapidly evolving genes associated with DNA damage repair (Atm and Pdia4) and male sperm quality (Idh3b and Atplb1) that aid in clarifying high-altitude adaptation of Neodon species. Additionally, we found that genes (Nrp2, Vav3, Cat and Adam8) associated with oxidative stress and cardiovascular regulation seem to have experienced convergent evolution among plateau species. Notably, we identified a Neodon-specific 24 bp deletion in Map3k6, which may regulate angiogenesis, aiding Neodon species adapt to hypoxic environments.ConclusionThese findings elucidate molecular mechanisms underlying high-altitude adaptation, emphasizing the integrative roles of immunity, stress response, and reproduction. The high-quality genome of N. fuscus offers new insights into how Neodon adapt to high-altitude environments and will facilitate future research on Neodon. |
| 源URL | [http://210.75.249.4/handle/363003/62429]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 推荐引用方式 GB/T 7714 | Yang, Peng,Qu, Jiapeng,Wang, Yingxu,et al. Chromosome-level genome of Neodon fuscus sheds light on the evolution and plateau adaptation of N. fuscus and Neodon[J]. BMC GENOMICS,2025,26(1). |
| APA | Yang, Peng.,Qu, Jiapeng.,Wang, Yingxu.,Xu, Zhongshi.,Feng, Tuo.,...&Sun, Ting.(2025).Chromosome-level genome of Neodon fuscus sheds light on the evolution and plateau adaptation of N. fuscus and Neodon.BMC GENOMICS,26(1). |
| MLA | Yang, Peng,et al."Chromosome-level genome of Neodon fuscus sheds light on the evolution and plateau adaptation of N. fuscus and Neodon".BMC GENOMICS 26.1(2025). |
入库方式： OAI收割
来源：西北高原生物研究所
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