Two novel phenolic glycosides from Saxifraga tangutica for NASH treatment: In vitro network pharmacology, and molecular docking analysis
文献类型：期刊论文
| 作者 | Liu, Chuang; Wang, Qilan; Lin, Zikai; Li, Gang; EI-Aty, A. M. Abd; Dang, Jun |
| 刊名 | ARABIAN JOURNAL OF CHEMISTRY
 |
| 出版日期 | 2025 |
| 卷号 | 18期号:6 |
| 关键词 | Chromatography Molecular docking NASH Network pharmacology Phenolic glycoside Saxifraga tangutica |
| 英文摘要 | Medicinal plants have emerged as valuable inspiration for novel drug discovery owing to their abundant secondary metabolites. This study aimed to further investigate the anti-non-alcoholic steatohepatitis (NASH) potential of secondary metabolites from the traditional Tibetan medicine (TTM) Saxifraga tangutica (S. tangutica). Using medium-pressure liquid chromatography (MPLC) and hydrophilic/reversed-phase liquid chromatography, nine high-purity (>95%) compounds were isolated, including two novel phenolic glycosides: beta-D-galactoside-1,6-bis(3,4,5-trihydroxybenzoate) and -(-)-rhododendron-4'-beta-D-glucoside. Pharmacological evaluation through Oil Red O staining coupled with comprehensive biochemical profiling demonstrated dose-dependent anti-NASH efficacy of the novel glycosides. Subsequent network pharmacology analysis identified the cAMP and sphingolipid signaling pathways as the principal molecular mechanisms. Molecular docking demonstrated that beta-D-galactopyranosyl-1,6-bis(3,4,5-trihydroxybenzoate) exhibited strong binding to HSP90AA1 (-8.65 kcal/mol), and (-)-rhododendrin-4 '-beta-D-glucopyranoside exhibited strong binding to NFE2L2 (-7.88 kcal/mol). Overall, this study further evaluated the medicinal potential of S. tangutica, while these two novel phenolic glycosides are anticipated to contribute valuable molecular backbones and targeting strategies for NASH drug discovery. |
| 源URL | [http://210.75.249.4/handle/363003/62431]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 推荐引用方式 GB/T 7714 | Liu, Chuang,Wang, Qilan,Lin, Zikai,et al. Two novel phenolic glycosides from Saxifraga tangutica for NASH treatment: In vitro network pharmacology, and molecular docking analysis[J]. ARABIAN JOURNAL OF CHEMISTRY,2025,18(6). |
| APA | Liu, Chuang,Wang, Qilan,Lin, Zikai,Li, Gang,EI-Aty, A. M. Abd,&Dang, Jun.(2025).Two novel phenolic glycosides from Saxifraga tangutica for NASH treatment: In vitro network pharmacology, and molecular docking analysis.ARABIAN JOURNAL OF CHEMISTRY,18(6). |
| MLA | Liu, Chuang,et al."Two novel phenolic glycosides from Saxifraga tangutica for NASH treatment: In vitro network pharmacology, and molecular docking analysis".ARABIAN JOURNAL OF CHEMISTRY 18.6(2025). |
入库方式： OAI收割
来源：西北高原生物研究所
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