High-fat diet-induced osteoporosis in mice under hypoxic conditions
文献类型：期刊论文
| 作者 | Qiao, Yajun; Zheng, Huimin; Cheng, Ruiying; Guo, Juan; Ji, Li; Liu, Zhibin; Wei, Lixin; Bi, Hongtao; Shan, Zhongshu |
| 刊名 | BMC MUSCULOSKELETAL DISORDERS
 |
| 出版日期 | 2025 |
| 卷号 | 26期号:1 |
| 关键词 | Hypoxia HFD Bone metabolism Gut |
| 英文摘要 | In the context of global aging, osteoporosis has emerged as a significant public health concern, with a relatively high prevalence observed in plateau regions. This study aimed to investigate the effects and underlying mechanisms of high-fat diet (HFD) and hypoxic conditions on bone metabolism in mice. The mice were subjected to different dietary regimens (a HFD versus a normal diet) and placed in a hypoxic environment. This study explored relevant mechanisms through comprehensive assessments, including body and bone morphological indices, pathological examinations, biochemical analyses, evaluation of gut microbiota diversity, and metabolomics approaches. The results indicated that, compared with those in the control group, the body weight, Lee's index, body mass index (BMI), and body fat percentage of the HFD-fed group were significantly greater. Additionally, the femoral microstructure was compromised, bone metabolic markers were disrupted, inflammatory responses were heightened, gut microbiota diversity was altered, and specific intestinal metabolites such as Anserine were downregulated, whereas L-carnosine was upregulated. Spearman correlation analysis and network visualization elucidated the multifactorial influence mechanism of a HFD on bone metabolism under hypoxic conditions. These factors interconnect to form a complex network that drives osteoporosis development. Notably, L-carnosine occupies a central position within this network, serving as a key hub for interactions among various factors. Under the dual stressors of hypoxia and a HFD, this network becomes imbalanced, leading to bone metabolic disorders and osteoporosis. This study provides insights into the multifactorial mechanisms of osteoporosis induced by a HFD and hypoxia in mice, offering a foundation for subsequent research and preventive strategies for osteoporosis in plateau areas. |
| 源URL | [http://210.75.249.4/handle/363003/62447]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 推荐引用方式 GB/T 7714 | Qiao, Yajun,Zheng, Huimin,Cheng, Ruiying,et al. High-fat diet-induced osteoporosis in mice under hypoxic conditions[J]. BMC MUSCULOSKELETAL DISORDERS,2025,26(1). |
| APA | Qiao, Yajun.,Zheng, Huimin.,Cheng, Ruiying.,Guo, Juan.,Ji, Li.,...&Shan, Zhongshu.(2025).High-fat diet-induced osteoporosis in mice under hypoxic conditions.BMC MUSCULOSKELETAL DISORDERS,26(1). |
| MLA | Qiao, Yajun,et al."High-fat diet-induced osteoporosis in mice under hypoxic conditions".BMC MUSCULOSKELETAL DISORDERS 26.1(2025). |
入库方式： OAI收割
来源：西北高原生物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。