A starch-like polysaccharide isolated from Hirsutella sinensis mycelia alleviates DSS-induced colitis in mice by strengthening the intestinal barrier, maintaining immune homeostasis, and modulating the gut microbiota and SCFA metabolism
文献类型：期刊论文
| 作者 | Li, Yu; Wang, Hailiang; Bi, Hongtao; Feng, Jingyue; Gao, Tingting; Dong, Dai; Li, Guoqiang; Liu, Boxuan; Yuan, Hongyan; Ni, Weihua |
| 刊名 | FOOD BIOSCIENCE
 |
| 出版日期 | 2025 |
| 卷号 | 68 |
| 关键词 | Hirsutella sinensis Polysaccharide Colitis Intestinal barrier Intestinal immune Gut microbiota |
| 英文摘要 | Hirsutella sinensis (H. sinensis), a substitute for a valuable edible and medicinal fungus, Cordyceps sinensis, is well known for its various of beneficial pharmacological properties. However, research on the effects of H. sinensis on colitis in mice is limited. In our previous studies, we carried out a systematic classification and structural identification of the polysaccharides in H. sinensis. Here, we utilized a murine model of colitis induced by a 3 % dextran sulfate sodium (DSS) administration to investigate the protective effects of the H. sinensis myceliumderived starch-like polysaccharide (HSWP-1a) on colitis. Our findings demonstrate that HSWP-1a effectively mitigates DSS-induced weight loss, reduces colon tissue damage, increases tight junction protein expression, and restores intestinal barrier function. Notably, during this process, HSWP-1a reversed the DSS-induced increase in M1/M2 macrophage polarization and the Th17/Treg cell balance, ameliorating the DSS-induced decrease in antiinflammatory cytokine expression while inhibiting the DSS-induced increase in proinflammatory cytokine levels and mediating immune tolerance to maintain local intestinal immune homeostasis. Furthermore, HSWP-1a is capable of regulating the intestinal microbiota, enhancing the abundance of beneficial bacteria such as Lachnospiraceae_NK4A136_group, and reducing the abundance of harmful bacteria like Proteobacteria and Cyanobacteria. HSWP-1a also restores the levels of short-chain fatty acids (SCFA) to maintain the balanced intestinal microenvironment. Overall, HSWP-1a achieves its colitis-protective effects through its ability to strengthen the intestinal barrier, regulate the immune system, and restore gut microbiota interactions. These findings suggest that HSWP-1a has potential as a valuable food supplement or nutritional health product for alleviating colitis. |
| 源URL | [http://210.75.249.4/handle/363003/62456]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 推荐引用方式 GB/T 7714 | Li, Yu,Wang, Hailiang,Bi, Hongtao,et al. A starch-like polysaccharide isolated from Hirsutella sinensis mycelia alleviates DSS-induced colitis in mice by strengthening the intestinal barrier, maintaining immune homeostasis, and modulating the gut microbiota and SCFA metabolism[J]. FOOD BIOSCIENCE,2025,68. |
| APA | Li, Yu.,Wang, Hailiang.,Bi, Hongtao.,Feng, Jingyue.,Gao, Tingting.,...&Ni, Weihua.(2025).A starch-like polysaccharide isolated from Hirsutella sinensis mycelia alleviates DSS-induced colitis in mice by strengthening the intestinal barrier, maintaining immune homeostasis, and modulating the gut microbiota and SCFA metabolism.FOOD BIOSCIENCE,68. |
| MLA | Li, Yu,et al."A starch-like polysaccharide isolated from Hirsutella sinensis mycelia alleviates DSS-induced colitis in mice by strengthening the intestinal barrier, maintaining immune homeostasis, and modulating the gut microbiota and SCFA metabolism".FOOD BIOSCIENCE 68(2025). |
入库方式： OAI收割
来源：西北高原生物研究所
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