Isolation and preparation of flavonoids from Glycyrrhiza uralensis fisch. Using multi-dimensional chromatography for treating non-alcoholic fatty liver disease
文献类型：期刊论文
| 作者 | Fang, Yan; Lin, Zikai; Lv, Yue; Ma, Chengjun; Wang, Zhenhua; Dang, Jun; Li, Gang |
| 刊名 | JOURNAL OF MOLECULAR STRUCTURE
 |
| 出版日期 | 2025 |
| 卷号 | 1340 |
| 关键词 | G. uralensis Flavonoids NAFLD Multi-dimensional reversed-phase system |
| 英文摘要 | Glycyrrhiza uralensis Fisch. (G. uralensis) is a traditional herbal medicine with significant hepatoprotective properties, as demonstrated by ongoing pharmacological studies. Flavonoids constitute the primary bioactive components of G. uralensis. This study investigates the flavonoids in G. uralensis that are effective in ameliorating non-alcoholic fatty liver disease (NAFLD). Based on activity screening results, high-pressure liquid chromatography was used to isolate six target flavonoid components (Fr826, licoricone; Fr8241, formononetin; Fr841, semilicoisoflavone B; Fr844, glyasperin D; Fr8421, glycyrin; and Fr8432, glycyrrhisoflavone) using a multidimensional reversed-phase system. The effects of these isolated flavonoids on NAFLD were assessed, and a preliminary structure-activity relationship analysis was conducted. Generally, the hydroxyl and oxygencontaining substituents on the A and B rings of these flavonoids significantly affect lipid-lowering activity, while the quantity and positional variation of isopentenyl groups may contribute to cellular damage. Thus, this study provides significant evidence supporting the therapeutic potential of G. uralensis flavonoids in NAFLD treatment. |
| 源URL | [http://210.75.249.4/handle/363003/62457]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 推荐引用方式 GB/T 7714 | Fang, Yan,Lin, Zikai,Lv, Yue,et al. Isolation and preparation of flavonoids from Glycyrrhiza uralensis fisch. Using multi-dimensional chromatography for treating non-alcoholic fatty liver disease[J]. JOURNAL OF MOLECULAR STRUCTURE,2025,1340. |
| APA | Fang, Yan.,Lin, Zikai.,Lv, Yue.,Ma, Chengjun.,Wang, Zhenhua.,...&Li, Gang.(2025).Isolation and preparation of flavonoids from Glycyrrhiza uralensis fisch. Using multi-dimensional chromatography for treating non-alcoholic fatty liver disease.JOURNAL OF MOLECULAR STRUCTURE,1340. |
| MLA | Fang, Yan,et al."Isolation and preparation of flavonoids from Glycyrrhiza uralensis fisch. Using multi-dimensional chromatography for treating non-alcoholic fatty liver disease".JOURNAL OF MOLECULAR STRUCTURE 1340(2025). |
入库方式： OAI收割
来源：西北高原生物研究所
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