A Study of Sex Differences in the Biological Pathways of Stress Regulation in Mice
文献类型：期刊论文
| 作者 | Qiao, Yajun; Chen, Hanxi; Guo, Juan; Zhang, Xingfang; Liang, Xinxin; Wei, Lixin; Wang, Qiannan; Bi, Hongtao; Gao, Tingting |
| 刊名 | CNS NEUROSCIENCE & THERAPEUTICS
 |
| 出版日期 | 2025 |
| 卷号 | 31期号:5 |
| 关键词 | behavior brain-gut axis depression sex differences stress |
| 英文摘要 | BackgroundStress is closely related to life, and it can also cause many mental disorders. However, there are significant sex differences in neuropsychiatric disorders associated with stress, particularly in depression, where the lifetime risk of depression in women is approximately twice that of men. However, the specific mechanism of this process has not been explained in detail.MethodsChronic restraint stress (CRS) + chronic and unpredictable mild stress (CUMS) was used to simulate social stress, and behavioral experiments, HE staining of rectal and hippocampal pathological sections, detection of depression-related biological indicators, analysis of intestinal flora diversity, and metabolomics analysis of hippocampal and intestinal contents were performed.ResultsThe results showed that stress induced anxiety-like behavior in female mice and depression-like behavior in male mice. Sex differences in behavior may be related to monoamine neurotransmitters, hyperactivity of HPA axis, inflammatory factors, gut microbiota, and brain-gut metabolism. It is worth noting that stress caused opposite trends in DA (dopamine) levels, abundance of f-lactobaciliaceae, and levels of metabolites (1, 2-distearoyl-SN-glycero-3-phosphocholine) and PC(20:5(5Z,8Z,11Z,14Z,17Z)/20:1(11Z)) in male and female mice.ConclusionThe difference in neurotransmitter levels, the disorder of gut microbiota, and the abnormal brain and gut metabolism may lead to the gender difference in stress behavior. |
| 源URL | [http://210.75.249.4/handle/363003/62458]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 推荐引用方式 GB/T 7714 | Qiao, Yajun,Chen, Hanxi,Guo, Juan,et al. A Study of Sex Differences in the Biological Pathways of Stress Regulation in Mice[J]. CNS NEUROSCIENCE & THERAPEUTICS,2025,31(5). |
| APA | Qiao, Yajun.,Chen, Hanxi.,Guo, Juan.,Zhang, Xingfang.,Liang, Xinxin.,...&Gao, Tingting.(2025).A Study of Sex Differences in the Biological Pathways of Stress Regulation in Mice.CNS NEUROSCIENCE & THERAPEUTICS,31(5). |
| MLA | Qiao, Yajun,et al."A Study of Sex Differences in the Biological Pathways of Stress Regulation in Mice".CNS NEUROSCIENCE & THERAPEUTICS 31.5(2025). |
入库方式： OAI收割
来源：西北高原生物研究所
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