Tentative characterization of three novel coumaroyl glucoside β-carboline alkaloids and discovery of hypoglycemic compounds from Nitraria tangutorum Bobr. Fruit
文献类型：期刊论文
| 作者 | Yue, Huilan; Li, Jiaxin; Wu, Li; Wang, Fei; Li, Zhen; Jiang, Sirong; Zhao, Xiaohui |
| 刊名 | FOOD CHEMISTRY
 |
| 出版日期 | 2025 |
| 卷号 | 481 |
| 关键词 | /3-Carboline alkaloids Cyclic dipeptide Depsides Sucrase and maltase inhibition Improving IR |
| 英文摘要 | Nitraria tangutorum Bobr. (NTB), mainly distributed in the Qaidam Basin, had high medicinal and ecological value, and research on its chemical components and bioactivities is necessary. In this study, three novel /3-carboline alkaloids tangutorid LI-III were isolated and tentatively identified from NTB fruit, which represent the first example of coumaroyl glucoside-derived /3-carboline alkaloids isolated from natural products. The possible biogenetic pathways and MS/MS fragmentation forms of tangutorid LI-III were also tentatively speculated, which provide theoretical basis for rapid identification of this type of components. Hypoglycemic activity research of isolated compounds confirmed that depsides (dihydroxybenzoyl-trihydroxyphenylmethylacetate, 14) not only had strong sucrase and maltase inhibitory activities, but also exhibited noteworthy insulin resistance (IR) ameliorative effects. In addition, cyclic dipeptide (cyclo (tyr-tyr), 10) was also demonstrated to have significant IR improvement effect. This study enriched the structural types of /3-carboline alkaloids in fruits and expanded the biological activity of cyclic dipeptide and depsides. |
| 源URL | [http://210.75.249.4/handle/363003/62488]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 推荐引用方式 GB/T 7714 | Yue, Huilan,Li, Jiaxin,Wu, Li,et al. Tentative characterization of three novel coumaroyl glucoside β-carboline alkaloids and discovery of hypoglycemic compounds from Nitraria tangutorum Bobr. Fruit[J]. FOOD CHEMISTRY,2025,481. |
| APA | Yue, Huilan.,Li, Jiaxin.,Wu, Li.,Wang, Fei.,Li, Zhen.,...&Zhao, Xiaohui.(2025).Tentative characterization of three novel coumaroyl glucoside β-carboline alkaloids and discovery of hypoglycemic compounds from Nitraria tangutorum Bobr. Fruit.FOOD CHEMISTRY,481. |
| MLA | Yue, Huilan,et al."Tentative characterization of three novel coumaroyl glucoside β-carboline alkaloids and discovery of hypoglycemic compounds from Nitraria tangutorum Bobr. Fruit".FOOD CHEMISTRY 481(2025). |
入库方式： OAI收割
来源：西北高原生物研究所
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