Responses of gut microbiota to altitude in a small mammal on Qinghai-Tibetan Plateau
文献类型：期刊论文
| 作者 | Zhang, Yan; Wang, Yihong; Yao, Baohui; Tan, Zhaoxian; Chen, Xinyang; Wang, Rong; Ji, Weihong; Qu, Jiapeng |
| 刊名 | COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS
 |
| 出版日期 | 2025 |
| 卷号 | 55 |
| 关键词 | Altitude Gut microbiota Microbial diversity Co-occurrence network Short-chain fatty acids |
| 英文摘要 | Altitude of the plateau may affect the composition and functional diversity of animal gut microbiota. However, the specific effects of altitude on the composition, community structure, and function of the host's gut microbiota, as well as how these effects, through interactions between microbial metabolic products (e.g., SCFAs) and microbial diversity, support host adaptation to high-altitude environments, remain unclear. This study investigates the variations of gut microbial community structure and function in plateau pikas (Ochotona curzoniae) along altitude on Qinghai-Tibetan Plateau. Cecum contents were analyzed using 16S rRNA sequencing and short-chain fatty acid (SCFA) content analyses to explore the structure, function and metabolic characteristics gut microbiota across different altitudes. As altitude increases, pikas' gut microbiota diversity significantly decreased, SCFA levels did not significantly change, while both diversity and complexity of the microbiota co-occurrence networks significantly decreased. The microbial community shifted toward better suited to high-altitude environments, as significantly increased in Bacteroidetes abundance but decreased in Firmicutes abundance. The microbial community assembly process became more deterministic, and KEGG analysis revealed the upregulation of metabolic, genetic information processing, and organismal system pathways. These results indicated that the gut microbiota diversity and complexity decreased in plateau pikas with increasing altitude, along with the upregulation of key metabolic pathways, as well as the stability of SCFA levels which reflecting balanced supply- demand relationships, contribute to adaptation of high-altitude environments. These findings reveal the substantial impact of altitude on the gut microbiota of a small mammal inhabiting the plateau, providing new insights into its adaptation mechanisms to high-altitude environments. |
| 源URL | [http://210.75.249.4/handle/363003/62505]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 推荐引用方式 GB/T 7714 | Zhang, Yan,Wang, Yihong,Yao, Baohui,et al. Responses of gut microbiota to altitude in a small mammal on Qinghai-Tibetan Plateau[J]. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS,2025,55. |
| APA | Zhang, Yan.,Wang, Yihong.,Yao, Baohui.,Tan, Zhaoxian.,Chen, Xinyang.,...&Qu, Jiapeng.(2025).Responses of gut microbiota to altitude in a small mammal on Qinghai-Tibetan Plateau.COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS,55. |
| MLA | Zhang, Yan,et al."Responses of gut microbiota to altitude in a small mammal on Qinghai-Tibetan Plateau".COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS 55(2025). |
入库方式： OAI收割
来源：西北高原生物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。