Effect of Yak Skin Gelatin with Different Molecular Weights on the Properties of Gelatin/Polymethyl Vinyl Ether-alt-maleic-anhydride Copolymer Composite Scaffold Material
文献类型：期刊论文
| 作者 | Zhang, Yuxia; Liu, Songhao; Rong, Lin; Gao, Liang; Wei, Lixin; Du, Yuzhi; Yang, Hongxia |
| 刊名 | ACS OMEGA
 |
| 出版日期 | 2025 |
| 卷号 | 10期号:10页码:9938 |
| 英文摘要 | Gelatin has been extensively documented for its utility in tissue engineering applications. However, the exploration of yak skin gelatin as a novel gelatin source remains under-reported, particularly regarding the impact of varying molecular weights on the attributes of composite scaffold materials. This study investigates the distinctive behaviors of yak skin gelatin fractions with different molecular weights, assessing fundamental properties through electrophoretic analysis, thermodynamic property assessment, amino acid profiling, infrared spectroscopy, and atomic force microscopy. Then, the polymethyl vinyl ether-alt-maleic-anhydride copolymer (PMVE-MA) was introduced to fabricate the composite scaffold materials. It was observed that the hemolysis rate escalated with increasing gelatin molecular weight. Additionally, properties such as platelet adhesion and mechanical stability exhibited a molecular-weight-dependent threshold behavior. Importantly, no cytotoxic effects were observed across all groups. Notably, scaffold materials fabricated by gelatin with a molecular weight range of 0.1-0.22 mu m demonstrated superior mechanical strength and cell adhesion, positioning them as optimal candidates for biodegradable vascular scaffold applications. |
| 源URL | [http://210.75.249.4/handle/363003/62510]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 推荐引用方式 GB/T 7714 | Zhang, Yuxia,Liu, Songhao,Rong, Lin,et al. Effect of Yak Skin Gelatin with Different Molecular Weights on the Properties of Gelatin/Polymethyl Vinyl Ether-alt-maleic-anhydride Copolymer Composite Scaffold Material[J]. ACS OMEGA,2025,10(10):9938. |
| APA | Zhang, Yuxia.,Liu, Songhao.,Rong, Lin.,Gao, Liang.,Wei, Lixin.,...&Yang, Hongxia.(2025).Effect of Yak Skin Gelatin with Different Molecular Weights on the Properties of Gelatin/Polymethyl Vinyl Ether-alt-maleic-anhydride Copolymer Composite Scaffold Material.ACS OMEGA,10(10),9938. |
| MLA | Zhang, Yuxia,et al."Effect of Yak Skin Gelatin with Different Molecular Weights on the Properties of Gelatin/Polymethyl Vinyl Ether-alt-maleic-anhydride Copolymer Composite Scaffold Material".ACS OMEGA 10.10(2025):9938. |
入库方式： OAI收割
来源：西北高原生物研究所
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