Hepatotoxic effects of environmentally relevant concentrations of polystyrene microplastics on senescent Zebrafish ( Danio rerio): Patterns of stress response and metabolomic alterations
文献类型：期刊论文
| 作者 | Xie, Pengfei; Ommati, Mohammad Mehdi; Chen, Deshan; Chen, Weijun; Han, Lei; Zhao, Xinquan; Wang, Hongwei; Xu, Shixiao; Sun, Ping |
| 刊名 | AQUATIC TOXICOLOGY
 |
| 出版日期 | 2025 |
| 卷号 | 279 |
| 关键词 | Environmental exposure Aged-animals Hepatic stress Metabolite profiling Microplastic pollution |
| 英文摘要 | The hepatotoxicity of microplastics (MPs) has garnered increasing attention, but their effects on elderly organisms remain inadequately characterized, particularly concerning hepatic stress response patterns in environmental conditions. In this study, a 10-day exposure period of elderly zebrafish to polystyrene microplastics (PS-MPs, 1 mu m) was conducted, with exposure concentrations set at 5.6 x 10-7 mu g/L, 5.6 x 10-4 mu g/L, and 5.6 x 10-1 mu g/L. PS-MPs-induced toxicity varied with concentration: superoxide dismutase (SOD), complement 3 (C3), and complement 4 (C4) initially decreased before rising; 8-hydroxy-2-deoxyguanosine (8-OhdG), interleukin-6 (IL-6), and interleukin-8 (IL-8) increased at high concentrations. Additionally, catalase (CAT) activity and thiobarbituric acid reactive substances (TBARS) contents rose with concentration. The aged zebrafish liver exhibited differentiation driven by responsiveness; low levels cause homeostatic disruption, and high levels induce genotoxicity and immune activation. LC-MS identified twelve crucial metabolites involved in 18 metabolic pathways, including amino acids (L-tyrosine, l-arginine), lipids (phospholipids, 12(S)-leukotriene B4 and triglycerides), and N-acetylneuraminic acid, related to energy, immunity, and neurological health. Overall, elderly zebrafish exhibited clear dose-dependent thresholds and distinct physiological stress responses under varying concentrations of PS-MPs. These findings reveal how PS-MP exposure can affect physiological health and metabolism, offering critical insights into the ecological risks faced by aging organisms. |
| 源URL | [http://210.75.249.4/handle/363003/62551]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 推荐引用方式 GB/T 7714 | Xie, Pengfei,Ommati, Mohammad Mehdi,Chen, Deshan,et al. Hepatotoxic effects of environmentally relevant concentrations of polystyrene microplastics on senescent Zebrafish ( Danio rerio): Patterns of stress response and metabolomic alterations[J]. AQUATIC TOXICOLOGY,2025,279. |
| APA | Xie, Pengfei.,Ommati, Mohammad Mehdi.,Chen, Deshan.,Chen, Weijun.,Han, Lei.,...&Sun, Ping.(2025).Hepatotoxic effects of environmentally relevant concentrations of polystyrene microplastics on senescent Zebrafish ( Danio rerio): Patterns of stress response and metabolomic alterations.AQUATIC TOXICOLOGY,279. |
| MLA | Xie, Pengfei,et al."Hepatotoxic effects of environmentally relevant concentrations of polystyrene microplastics on senescent Zebrafish ( Danio rerio): Patterns of stress response and metabolomic alterations".AQUATIC TOXICOLOGY 279(2025). |
入库方式： OAI收割
来源：西北高原生物研究所
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