Supramolecular prodrug vesicles for selective antimicrobial therapy employing a chemo-photodynamic strategy
文献类型：期刊论文
| 作者 | Sun, Hao; Li, Shengke; Liu, Qian; Zuo, Minzan; Tian, Xueqi; Wang, Kaiya; Hu, Xiao-Yu |
| 刊名 | CHINESE CHEMICAL LETTERS
 |
| 出版日期 | 2025 |
| 卷号 | 36期号:3 |
| 关键词 | Supramolecular prodrug Selective antibacterial activity Host-guest complex Cavitand Combination therapy |
| 英文摘要 | Supramolecular prodrug vesicles ( H-4 superset of B-2 @MB) with selective antibacterial activity have been successfully constructed. Specifically, a natural antibiotic prodrug ( B-2 ) with glutathione (GSH)-responsiveness was synthesized. The hydrophobic interaction between B-2 and a novel water-soluble cavitand with deep cavity ( H-4 ) resulted in the formation of a host-guest complex, which further self-assembled into supramolecular vesicles. The formed vesicles could effectively encapsulate the photosensitizer methylene blue (MB), enabling co-delivery of antibiotics and photosensitizers in the presence of GSH. Moreover, upon excitation at 630nm, the photosensitizers generate reactive oxygen species (ROS), effectively eradicating E. coli through combined chemo-photodynamic therapy. Considering that GSH is predominantly present in Gram-negative bacteria such as E. coli, this strategy exhibits substantial potential for selectively inhibiting bacteria characterized by high GSH levels to regulate bacterial colony equilibrium. (c) 2025 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. |
| 源URL | [http://210.75.249.4/handle/363003/62562]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 推荐引用方式 GB/T 7714 | Sun, Hao,Li, Shengke,Liu, Qian,et al. Supramolecular prodrug vesicles for selective antimicrobial therapy employing a chemo-photodynamic strategy[J]. CHINESE CHEMICAL LETTERS,2025,36(3). |
| APA | Sun, Hao.,Li, Shengke.,Liu, Qian.,Zuo, Minzan.,Tian, Xueqi.,...&Hu, Xiao-Yu.(2025).Supramolecular prodrug vesicles for selective antimicrobial therapy employing a chemo-photodynamic strategy.CHINESE CHEMICAL LETTERS,36(3). |
| MLA | Sun, Hao,et al."Supramolecular prodrug vesicles for selective antimicrobial therapy employing a chemo-photodynamic strategy".CHINESE CHEMICAL LETTERS 36.3(2025). |
入库方式： OAI收割
来源：西北高原生物研究所
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