A Study on the Anti-inflammatory Activity of Clematis tangutica Using Molecular Networking
文献类型：期刊论文
| 作者 | Li, Aijing; Chen, Tao; Wang, Shuo; Luo, Juyuan; Shen, Cheng; Li, Hongmei; Ma, Yumei; Song, Zhibo; Lu, Weihang; Zou, Denglang |
| 刊名 | CURRENT ANALYTICAL CHEMISTRY
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| 出版日期 | 2025 |
| 卷号 | 21期号:8页码:1063 |
| 关键词 | Activity labelled molecular networking anti-inflammatory molecules Clematis tangutica LC-MS metabolism study structural annotation |
| 英文摘要 | Background Clematis tangutica, an indigenous medicinal herb native to the Qinghai-Tibet Plateau of China, has traditionally been associated with treating various inflammation-related diseases. While its therapeutic potential is recognized, a comprehensive characterization of its metabolite molecules and their anti-inflammatory properties has not been undertaken.Objective This study aimed to comprehensively profile the metabolite molecules of Clematis tangutica and identify potential anti-inflammatory active molecules using the Activity Labelled Molecular Networking (ALMN) approach.Methods The ALMN approach was employed to visually label activity to the feature-based molecular network, allowing for the profiling of potential anti-inflammatory active molecules in Clematis tangutica. Through correlating activity levels with the respective molecules, a detailed profiling was achieved.Results Out of the 8,644 metabolite molecules in Clematis tangutica, ten were identified as the most potent anti-inflammatory molecules. Among these, Spiraeoside was notably annotated along with its structure.Conclusion This research successfully identified ten potent anti-inflammatory molecules from the vast metabolite profile of Clematis tangutica, including a detailed annotation of Spiraeoside. This marked a significant step in bridging traditional therapeutic knowledge with modern molecular profiling techniques. |
| 源URL | [http://210.75.249.4/handle/363003/62568]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 推荐引用方式 GB/T 7714 | Li, Aijing,Chen, Tao,Wang, Shuo,et al. A Study on the Anti-inflammatory Activity of Clematis tangutica Using Molecular Networking[J]. CURRENT ANALYTICAL CHEMISTRY,2025,21(8):1063. |
| APA | Li, Aijing.,Chen, Tao.,Wang, Shuo.,Luo, Juyuan.,Shen, Cheng.,...&Li, Yulin.(2025).A Study on the Anti-inflammatory Activity of Clematis tangutica Using Molecular Networking.CURRENT ANALYTICAL CHEMISTRY,21(8),1063. |
| MLA | Li, Aijing,et al."A Study on the Anti-inflammatory Activity of Clematis tangutica Using Molecular Networking".CURRENT ANALYTICAL CHEMISTRY 21.8(2025):1063. |
入库方式： OAI收割
来源：西北高原生物研究所
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