Human bare and clothing-covered skin exposure to chlorinated paraffins for the general populations: Exposure pattern differential and significance of indirect dermal exposure via clothing-to-skin transport
文献类型：期刊论文
| 作者 | Zhu, Chunyou1,2; Cao, Zhiguo2; Hu, Beibei3; Li, Zhi3; Huang, Simin4; Han, Xu2; Luo, Xiaojun5; Yuan, Haoran1; Li, Liangzhong1 |
| 刊名 | ENVIRONMENT INTERNATIONAL
 |
| 出版日期 | 2024-10-01 |
| 卷号 | 192页码:8 |
| 关键词 | Chlorinated paraffins Dermal exposure Bare skin Clothing-covered skin areas Oral ingestion |
| ISSN号 | 0160-4120 |
| DOI | 10.1016/j.envint.2024.109068 |
| 通讯作者 | Li, Liangzhong(lilz@ms.giec.ac.cn) |
| 英文摘要 | To investigate human exposure to short-chain chlorinated paraffins (SCCPs) and medium-chain chlorinated paraffins (MCCPs) through dermal and oral intake via hand-to-mouth contact, wipes from the face, forearm, hand, and foot of 30 volunteers were sampled. The concentration of SCCPs and MCCPs ranged from 0.66 to 119 and 0.71 to 565 mu g/m2, respectively. Hands exhibited significantly higher CPs concentrations than other skin areas, indicating that direct contact with indoor surfaces contributed considerable CP levels on this bare skin area. Gender differences in CP levels were observed in wipes from all locations, except for the hands, possibly because of the significant variability in residuals on the hands. A significant positive relationship was found between CP levels on the hands and faces, and the CP ratios of the hands/faces were related to log KOA. Bare skin showed more significant variations in CP partitioning among related congeners and between genders than skin covered by clothing, as elucidated by the linear analysis of RSD and log KOA. Although concentrations on clothing-covered areas were relatively lower than on bare skin, the median estimated dermal absorption doses of SCCPs and MCCPs (152 and 737 ng/kg bw/day, respectively) for the entire body were approximately 1-2 orders of magnitude higher than those for oral ingestion (1.62 and 7.94 ng/kg bw/day, respectively), emphasizing indirect dermal uptake as a significant exposure pathway for humans. |
| WOS关键词 | PEARL RIVER DELTA ; SHORT-CHAIN ; TEMPORAL TRENDS ; FLAME RETARDANTS ; MARINE MAMMALS ; INHALATION ; CHINA ; AIR ; SEDIMENTS ; PROFILES |
| 资助项目 | National Natural Science Foundation of China[42377489] ; National Natural Science Foundation of China[42307285] ; National Natural Science Foundation of China[42207493] ; National Natural Science Foundation of China[42307530] ; Guang-dong Basic and Applied Basic Research Foundation[2022A1515010346] ; Guang-dong Basic and Applied Basic Research Foundation[2020A1515110525] ; Science and Technology Program of Guangzhou, China[202201011626] |
| WOS研究方向 | Environmental Sciences & Ecology |
| 语种 | 英语 |
| WOS记录号 | WOS:001336532600001 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 资助机构 | National Natural Science Foundation of China ; Guang-dong Basic and Applied Basic Research Foundation ; Science and Technology Program of Guangzhou, China |
| 源URL | [http://ir.giec.ac.cn/handle/344007/43242]  |
| 专题 | 中国科学院广州能源研究所 |
| 通讯作者 | Li, Liangzhong |
| 作者单位 | 1.Chinese Acad Sci, Guangzhou Inst Energy Convers, Guangdong Prov Key Lab High Qual Recycling End Lif, Guangzhou 510640, Peoples R China 2.Henan Normal Univ, Sch Environm, Key Lab Yellow River & Huai River Water Environm &, Minist Educ, Xinxiang 453007, Peoples R China 3.Southern Marine Sci & Engn Guangdong Lab Guangzhou, Guangzhou 511458, Peoples R China 4.Guangzhou Med Univ, Affiliated Hosp 2, Dept Hepatobiliary Surg, Guangzhou 510260, Peoples R China 5.Chinese Acad Sci, Guangzhou Inst Geochem, State Key Lab Organ Geochem, Guangdong Prov Key Lab Environm Protect & Resource, Guangzhou 510640, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhu, Chunyou,Cao, Zhiguo,Hu, Beibei,et al. Human bare and clothing-covered skin exposure to chlorinated paraffins for the general populations: Exposure pattern differential and significance of indirect dermal exposure via clothing-to-skin transport[J]. ENVIRONMENT INTERNATIONAL,2024,192:8. |
| APA | Zhu, Chunyou.,Cao, Zhiguo.,Hu, Beibei.,Li, Zhi.,Huang, Simin.,...&Li, Liangzhong.(2024).Human bare and clothing-covered skin exposure to chlorinated paraffins for the general populations: Exposure pattern differential and significance of indirect dermal exposure via clothing-to-skin transport.ENVIRONMENT INTERNATIONAL,192,8. |
| MLA | Zhu, Chunyou,et al."Human bare and clothing-covered skin exposure to chlorinated paraffins for the general populations: Exposure pattern differential and significance of indirect dermal exposure via clothing-to-skin transport".ENVIRONMENT INTERNATIONAL 192(2024):8. |
入库方式： OAI收割
来源：广州能源研究所
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