Ultra-bright near-infrared reporters-embedded SERS nanotags library for single-animal multiplex monitoring protein-specific nanomaterial fate in vivo
文献类型：期刊论文
| 作者 | Mei, Rongchao1; Wang, Yunqing1,3; Zhao, Xizhen3; Wang, Qishuo3; Wang, Xiaoyan1; Chen, Lingxin1,2,3 |
| 刊名 | SENSORS AND ACTUATORS B-CHEMICAL
 |
| 出版日期 | 2026-02-01 |
| 卷号 | 448页码:9 |
| 关键词 | SERS tags NIR reporters Au shell Multiple detection Protein crowns |
| DOI | 10.1016/j.snb.2025.139026 |
| 通讯作者 | Wang, Yunqing(yqwang@yic.ac.cn) ; Chen, Lingxin(lxchen@yic.ac.cn) |
| 英文摘要 | An ultra-bright near-infrared (NIR) surface-enhanced Raman scattering (SERS) tag library is essential for multiplexed investigation of nanomaterial in vivo fate. Herein, we developed a versatile strategy exploiting phospholipid bilayer retention and KI-mediated etching to fabricate diverse Au core-shell-based NIR-SERS tags. These novel tags exhibit > 40-fold signal enhancement compared to conventional Au nanostar tags, enabling singleparticle detection and deep-tissue penetration up to 3 cm, surpassing the conventional millimeter-depth limit. This breakthrough facilitates the in vivo penetration detection of weakly bonded NIR-dye SERS tags, significantly enriching the NIR-SERS tag repertoire. To probe the influence of pre-modified proteins on nanomaterial biodistribution, we achieved simultaneous multiplexed detection of three distinct NIR-SERS tags labeled silica nanoparticles, pre-modified with globulin, human serum albumin (HSA), or transferrin, within a single mouse for the first time. ICP-MS validation revealed HSA modification significantly increased nanomaterial accumulation in the liver, spleen, and lung, while attenuating blood clearance by 45.6 %. Importantly, altering the premodified protein type directly modulated in vivo elimination and distribution; for instance, transferrin modification reduced liver accumulation by 53.4 % relative to HSA modification. This work provides a powerful platform for rapid multiplexed monitoring nanomaterial fate in vivo, offering critical insights into the way of regulating nanotoxicology and designing targeted nanomedicines. |
| WOS关键词 | GOLD NANOPARTICLES ; RAMAN ; TAGS |
| WOS研究方向 | Chemistry ; Electrochemistry ; Instruments & Instrumentation |
| 语种 | 英语 |
| WOS记录号 | WOS:001612003800001 |
| 资助机构 | National Natural Science Foundation of China ; Taishan Scholar Project Special Funding ; Development Plan of Youth Innovation Team in Colleges and Univer-sities of Shandong Province ; Special Fund for Leading Scholar Program of Yantai |
| 源URL | [http://ir.yic.ac.cn/handle/133337/41597]  |
| 专题 | 烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室 |
| 通讯作者 | Wang, Yunqing; Chen, Lingxin |
| 作者单位 | 1.Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China 2.Shaoxing Univ, Inst Adv Study, Shaoxing 312000, Peoples R China 3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China |
| 推荐引用方式 GB/T 7714 | Mei, Rongchao,Wang, Yunqing,Zhao, Xizhen,et al. Ultra-bright near-infrared reporters-embedded SERS nanotags library for single-animal multiplex monitoring protein-specific nanomaterial fate in vivo[J]. SENSORS AND ACTUATORS B-CHEMICAL,2026,448:9. |
| APA | Mei, Rongchao,Wang, Yunqing,Zhao, Xizhen,Wang, Qishuo,Wang, Xiaoyan,&Chen, Lingxin.(2026).Ultra-bright near-infrared reporters-embedded SERS nanotags library for single-animal multiplex monitoring protein-specific nanomaterial fate in vivo.SENSORS AND ACTUATORS B-CHEMICAL,448,9. |
| MLA | Mei, Rongchao,et al."Ultra-bright near-infrared reporters-embedded SERS nanotags library for single-animal multiplex monitoring protein-specific nanomaterial fate in vivo".SENSORS AND ACTUATORS B-CHEMICAL 448(2026):9. |
入库方式： OAI收割
来源：烟台海岸带研究所
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