Identification of PARPs and their potential role in longevity for larger Argopecten scallops to increase production
文献类型：期刊论文
| 作者 | Zhang, Zebin2; Sun, Lidong1; Wang, Rui2; Lin, Jieshan2; Gong, Zhiqian2; Cao, Haowen2; Zhao, Yang3; Jiang, Nan2; Wang, Chunde3; Lu, Xia2 |
| 刊名 | AQUACULTURE REPORTS
 |
| 出版日期 | 2025-12-30 |
| 卷号 | 45页码:18 |
| 关键词 | Argopecten scallops PARPs Genomic stability Lifespan Ionizing radiation |
| ISSN号 | 2352-5134 |
| DOI | 10.1016/j.aqrep.2025.103211 |
| 通讯作者 | Lu, Xia(luxia_0202@163.com) |
| 英文摘要 | The bay scallop (Argopecten irradians) is an important species in the fisheries and aquaculture industries. However, the bay scallop's small size, short lifespan (less than 14 months), and severe inbreeding depression present challenges for its sustainable development. Hybrids between the bay scallop and Peruvian scallop (A. purpuratus) are typically larger and longer-lived, likely due to longevity genes inherited from the Peruvian scallop (which has a lifespan of 7-10 years). Poly(ADP-ribose) polymerase (PARP) proteins play a crucial role in pathways related to aging. Specifically, DNA-dependent PARPs (PARP1, PARP2, and PARP3) are involved in maintaining genomic stability by responding to DNA breaks, but little is known about their role in the marine animals. In this study, we characterized the PARP gene family in both scallop species, identifying 38 members in the bay scallop and 30 in the Peruvian scallop, and observed differences in gene count, chromosomal localization, sequence structure, and alternative splicing between the two species. Cloning and sequencing of PARP1, PARP2, and PARP3 revealed significant differences in amino acid sequences between the two species that might affect protein function. Notably, reduced activity of PARP1-3 in short-lived bay scallops might potentially influence their lifespan. Exposure to ionizing radiation revealed substantial expression differences in PARPs and related genes between the two species. Additionally, the Peruvian scallop showed a significant upregulation of DNA-dependent PARPs, which may enhance its ability to maintain genomic stability. In conclusion, this study provides preliminary insights into the potential mechanisms by which PARPs may participate in DNA damage repair to maintain genomic stability for regulating the lifespan of marine bivalves. It may also identify potential biomarkers for breeding larger, longer-lived scallops to improve the production of their aquaculture. |
| WOS关键词 | POLY(ADP-RIBOSE) POLYMERASE-ACTIVITY ; IRRADIANS-IRRADIANS LAMARCK ; DNA-DAMAGE REPAIR ; SHORT LIFE-SPAN ; BAY SCALLOP ; NUCLEAR PROTEASOME ; EXPRESSION PROFILE ; ACTIVATION ; GENES ; HEPATOPANCREAS |
| WOS研究方向 | Fisheries |
| 语种 | 英语 |
| WOS记录号 | WOS:001614352700001 |
| 资助机构 | National Natural Science Foundation of China |
| 源URL | [http://ir.yic.ac.cn/handle/133337/41603]  |
| 专题 | 海岸带生物学与生物资源利用重点实验室 |
| 通讯作者 | Lu, Xia |
| 作者单位 | 1.Yantai Marine Econ Res Inst, Yantai 264003, Shandong, Peoples R China 2.Yantai Univ, Sch Ocean, Yantai 264005, Shandong, Peoples R China 3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res & Dev Ctr Efficient Utilizat Coastal Bioresour, Yantai 264003, Shandong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Zebin,Sun, Lidong,Wang, Rui,et al. Identification of PARPs and their potential role in longevity for larger Argopecten scallops to increase production[J]. AQUACULTURE REPORTS,2025,45:18. |
| APA | Zhang, Zebin.,Sun, Lidong.,Wang, Rui.,Lin, Jieshan.,Gong, Zhiqian.,...&Lu, Xia.(2025).Identification of PARPs and their potential role in longevity for larger Argopecten scallops to increase production.AQUACULTURE REPORTS,45,18. |
| MLA | Zhang, Zebin,et al."Identification of PARPs and their potential role in longevity for larger Argopecten scallops to increase production".AQUACULTURE REPORTS 45(2025):18. |
入库方式： OAI收割
来源：烟台海岸带研究所
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