Metabolite-driven reprogramming of bacterial persisters: Mechanisms and therapeutic opportunities for overcoming antibiotic tolerance
文献类型：期刊论文
| 作者 | Song, Yixiao3; Ye, Zifan1,3; Wang, Yipeng2,3 |
| 刊名 | DRUG RESISTANCE UPDATES
 |
| 出版日期 | 2026 |
| 卷号 | 84页码:21 |
| 关键词 | Bacterial persisters antibiotic tolerance metabolic reprogramming exogenous metabolites |
| ISSN号 | 1368-7646 |
| DOI | 10.1016/j.drup.2025.101322 |
| 通讯作者 | Wang, Yipeng(ypwang@yic.ac.cn) |
| 英文摘要 | Bacterial persisters constitute a heterogeneous subpopulation of dormant or slow-growing cells capable of surviving harsh environmental conditions, including antibiotic exposure. These cells are strongly associated with the failure of clinical antibiotic therapies and the recurrence of chronic bacterial infections. A comprehensive understanding of the physiological features of bacterial persisters is therefore critical for the development of targeted interventions aimed at overcoming the limitations of conventional antibiotic treatments. In this review, we summarize current models of bacterial persister formation, with particular emphasis on the pivotal role of reduced metabolic activity in mediating antibiotic tolerance. We further elucidate the mechanisms through which exogenous metabolites-such as sugars, lipids, and nucleic acid derivatives-induce metabolic reprogramming, thereby reversing multidrug resistance in bacterial persisters. Furthermore, we summarized the major barriers limiting the clinical translation of metabolite-assisted "wake-and-kill" strategies and outlined future prospects for their application. In conclusion, restoring bacterial metabolic activity through targeted metabolite interventions represents a promising avenue to overcome antibiotic tolerance, paving the way for nextgeneration therapeutic strategies against persistent infections. |
| WOS关键词 | TOXIN-ANTITOXIN SYSTEMS ; PSEUDOMONAS-AERUGINOSA ; STAPHYLOCOCCUS-AUREUS ; DRUG TOLERANCE ; RESISTANCE ; STRESS ; EVOLUTION ; AMINOGLYCOSIDES ; SUSCEPTIBILITY ; ERADICATION |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001614330800002 |
| 资助机构 | National Natural Science Foundation of China ; Key Research & Development Plan in Social Development of Jiangsu Province |
| 源URL | [http://ir.yic.ac.cn/handle/133337/41609]  |
| 专题 | 海岸带生物学与生物资源利用重点实验室 |
| 通讯作者 | Wang, Yipeng |
| 作者单位 | 1.Soochow Univ, Coll Pharmaceut Sci, Dept Biopharmaceut Sci, Suzhou 215123, Jiangsu, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Shandong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Song, Yixiao,Ye, Zifan,Wang, Yipeng. Metabolite-driven reprogramming of bacterial persisters: Mechanisms and therapeutic opportunities for overcoming antibiotic tolerance[J]. DRUG RESISTANCE UPDATES,2026,84:21. |
| APA | Song, Yixiao,Ye, Zifan,&Wang, Yipeng.(2026).Metabolite-driven reprogramming of bacterial persisters: Mechanisms and therapeutic opportunities for overcoming antibiotic tolerance.DRUG RESISTANCE UPDATES,84,21. |
| MLA | Song, Yixiao,et al."Metabolite-driven reprogramming of bacterial persisters: Mechanisms and therapeutic opportunities for overcoming antibiotic tolerance".DRUG RESISTANCE UPDATES 84(2026):21. |
入库方式： OAI收割
来源：烟台海岸带研究所
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