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Polymeric Membrane Potentiometric Ion Sensors with Dual Biocompatible Functionality

文献类型：期刊论文

作者Liu, Zhe1,5; Wang, Peng3; Zhao, Haijie1,5; Liu, Aohua4,5; Liang, Rongning2,5,6; Qin, Wei2,5,6
刊名ANALYTICAL CHEMISTRY
出版日期2025-11-25
卷号97期号:46页码:25567-25575
ISSN号0003-2700
DOI10.1021/acs.analchem.5c04116
通讯作者Liang, Rongning(rnliang@yic.ac.cn) ; Qin, Wei(wqin@yic.ac.cn)
英文摘要Polymeric membrane ion-selective electrodes (ISEs) have been routinely used to detect clinically important ions in physiological samples. However, the development of biocompatible potentiometric ion sensors for long-term measurements remains a significant challenge. Herein, a polymeric membrane Ca2+-ISE with dual biocompatible functionality (i.e., antibiofouling and low-cytotoxicity properties) is proposed. It is based on a semifluorinated, plasticizer-free sensing membrane with an immobilized ionophore. A new semifluorinated copolymer, 1H,1H,2H,2H-perfluorooctyl methacrylate-lauryl methacrylate (PFMA-LMA), has been synthesized. The low surface energy of the semifluorinated membrane could effectively prevent the surface adsorption of foulants such as lipids, proteins, and blood cells from biological samples. The immobilization of the sensing component and the plasticizer-free approach could significantly reduce the physiological toxicity of the sensor. Compared to the conventional plasticized poly(vinyl chloride) (PVC)-based membrane Ca2+-ISE, the bifunctional, biocompatible PFMA-LMA membrane electrode exhibits significantly reduced blood cell adhesion and cytotoxicity. The present sensor could be used for continuous real-time monitoring of Ca2+ in human blood for at least 3 days. The proposed strategy of dual biocompatible functionality has promising potential for the development of implantable and wearable polymeric membrane-based electrochemical and optical sensors.
WOS关键词POLY(VINYL CHLORIDE) MEMBRANES ; PLASTICIZER-FREE POLYMER ; SELECTIVE ELECTRODES ; BLOOD COMPATIBILITY ; CHEMICAL SENSORS ; NONIONIC SURFACTANTS ; PHOSPHORYLCHOLINE ; IONOPHORES ; CHALLENGES ; MATRICES
WOS研究方向Chemistry
语种英语
WOS记录号WOS:001612282100001
资助机构Taishan Scholar Project of Shandong Province ; Centre for Ocean Mega-Research of Science, Chinese Academy of Sciences ; Key Technology Research and Development Program of Shandong Province ; National Natural Science Foundation of China ; National Key Research and Development Program of China ; Special Supporting Project of Yantai
源URL[http://ir.yic.ac.cn/handle/133337/41618]  
专题烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室
通讯作者Liang, Rongning; Qin, Wei
作者单位1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
2.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Shandong, Peoples R China
3.B&E Biotechnol Co Ltd, Yantai 264003, Shandong, Peoples R China
4.Binzhou Med Univ, Sch Pharm, Yantai 264003, Shandong, Peoples R China
5.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Shandong Key Lab Coastal Environm Proc, Yantai 264003, Shandong, Peoples R China
6.Qingdao Marine Sci & Technol Ctr, Lab Marine Biol & Biotechnol, Qingdao 266237, Shandong, Peoples R China
推荐引用方式
GB/T 7714		 Liu, Zhe,Wang, Peng,Zhao, Haijie,et al. Polymeric Membrane Potentiometric Ion Sensors with Dual Biocompatible Functionality[J]. ANALYTICAL CHEMISTRY,2025,97(46):25567-25575.
APA Liu, Zhe,Wang, Peng,Zhao, Haijie,Liu, Aohua,Liang, Rongning,&Qin, Wei.(2025).Polymeric Membrane Potentiometric Ion Sensors with Dual Biocompatible Functionality.ANALYTICAL CHEMISTRY,97(46),25567-25575.
MLA Liu, Zhe,et al."Polymeric Membrane Potentiometric Ion Sensors with Dual Biocompatible Functionality".ANALYTICAL CHEMISTRY 97.46(2025):25567-25575.

入库方式： OAI收割

来源：烟台海岸带研究所

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