Dipeptidyl Peptidase IV Activated Near-Infrared Fluorescent Probe for Visually Evaluating Diabetes Models under Microplastic Exposure
文献类型：期刊论文
| 作者 | Sun, Xiao4,5; Huang, Yan5; Fu, Lili2,3; Wang, Xinlei5; Li, Shuang5; Wang, Xiaoyan3,5; Chen, Lingxin1,3,5; Zhao, Yu-Qing5 |
| 刊名 | ANALYTICAL CHEMISTRY
 |
| 出版日期 | 2025-11-21 |
| 页码 | 11 |
| ISSN号 | 0003-2700 |
| DOI | 10.1021/acs.analchem.5c05216 |
| 通讯作者 | Huang, Yan(yhuang@bzmc.edu.cn) ; Chen, Lingxin(lxchen@yic.ac.cn) ; Zhao, Yu-Qing(zhaoyuqing@bzmc.edu.cn) |
| 英文摘要 | The health of patients with type 2 diabetes mellitus (T2DM) may be adversely affected by microplastics (MPs) that are present in the environment. However, most toxicity studies of MPs are conducted on healthy models, which may not accurately reflect the exposure risks for diabetic individuals. Dipeptidyl peptidase IV (DPP4/CD26) is a multifunctional transmembrane glycoprotein with a broad spectrum of biological functions, and its abnormal activity is intimately associated with the development of T2DM. Therefore, noninvasive detection techniques for DPP4 have wide-ranging applications in disease diagnosis and MPs toxicity research. Here, we developed an enzyme-activatable near-infrared fluorescent probe, Cy-DPP, to monitor DPP4 activity in cells and mice exposed to MPs. Using this probe, we detected changes in DPP4 levels in healthy model mice and T2DM mouse models after exposure to MPs, respectively. Our results revealed a differential upregulation of DPP4, with varying degrees of increase observed between T2DM cells and mouse models. This study not only offers a new approach for the early diagnosis of T2DM but also highlights the significant impact of MPs on the diabetic condition. |
| WOS关键词 | DPP4 ; INFLAMMATION ; SITAGLIPTIN ; EXPRESSION ; INHIBITOR ; PATHWAY ; DISEASE ; GENES |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001620835100001 |
| 资助机构 | Taishan Scholar Project of Shandong Province ; Yantai Science and Technology Bureau ; National Natural Science Foundation of China ; Binzhou Medical University |
| 源URL | [http://ir.yic.ac.cn/handle/133337/41649]  |
| 专题 | 烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室 |
| 通讯作者 | Huang, Yan; Chen, Lingxin; Zhao, Yu-Qing |
| 作者单位 | 1.Shaoxing Univ, Coll Chem & Chem Engn, Shaoxing 312000, Peoples R China 2.Shandong Normal Univ, Coll Chem Chem Engn & Mat Sci, Jinan 250014, Peoples R China 3.Chinese Acad Sci, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 4.Qilu Inst Technol, Coll Biol & Chem Engn, Jinan 250200, Peoples R China 5.Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Xiao,Huang, Yan,Fu, Lili,et al. Dipeptidyl Peptidase IV Activated Near-Infrared Fluorescent Probe for Visually Evaluating Diabetes Models under Microplastic Exposure[J]. ANALYTICAL CHEMISTRY,2025:11. |
| APA | Sun, Xiao.,Huang, Yan.,Fu, Lili.,Wang, Xinlei.,Li, Shuang.,...&Zhao, Yu-Qing.(2025).Dipeptidyl Peptidase IV Activated Near-Infrared Fluorescent Probe for Visually Evaluating Diabetes Models under Microplastic Exposure.ANALYTICAL CHEMISTRY,11. |
| MLA | Sun, Xiao,et al."Dipeptidyl Peptidase IV Activated Near-Infrared Fluorescent Probe for Visually Evaluating Diabetes Models under Microplastic Exposure".ANALYTICAL CHEMISTRY (2025):11. |
入库方式： OAI收割
来源：烟台海岸带研究所
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