Spiroconyone B and C, Two Rearranged Cholestane Steroids with Spiro[4.5]decane and Oxaspiro[4.5]decane Scaffolds from Patiria pectinifera
文献类型：期刊论文
| 作者 | Zhang, Ran-Ran3,4; Lu, Zhen3; Shi, Qiang-Qiang5; Yan, Zhi3,4; Abdelwahab, Ghada M.6; Khalil, Ashraf T.6; Sun, Xue-Ting3; Li, Xiao-Dong3; Yin, Xiu-Li3; Abdelmohsen, Usama Ramadan1,2 |
| 刊名 | JOURNAL OF NATURAL PRODUCTS
 |
| 出版日期 | 2025-11-27 |
| 页码 | 9 |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/acs.jnatprod.5c01100 |
| 通讯作者 | Li, Ke(kli@yic.ac.cn) |
| 英文摘要 | Spiroconyone B (1) and C (2), two unique steroids bearing rare spiro[4.5]decane and oxaspiro[4.5]decane scaffolds, along with four analogues (3-6) were isolated from the sea star Patiria pectinifera. Structures were established by comprehensive spectroscopic analysis, quantum-chemical nuclear magnetic resonance calculations, electronic circular dichroism data, and single-crystal X-ray diffraction. Compounds 1, 4, and 5 exhibited cytotoxicity toward HL-60 cells with IC50 values of 7.6 +/- 0.3, 3.6 +/- 0.1, and 6.0 +/- 0.5 mu M, respectively. Flow cytometry indicated that 4 induced G2/M phase arrest, and annexin V/PI assays showed dose-dependent increases in the level of total apoptosis for 1 and 4. Western blotting revealed downregulation of cyclin B1 and cdc2 (CDK1) by 4; both 1 and 4 decreased Bcl-2 and increased Bax, consistent with mitochondria-mediated apoptosis. Network pharmacology, supported by mechanistic assays, further suggested the engagement of the PI3K/Akt pathway by 4. |
| WOS关键词 | SHIFTS ; ASSAY |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001627277600001 |
| 资助机构 | Chinese Academy of Sciences ; National Natural Science Foundation of China ; Yantai Science and Technology Innovation Development Program ; National Key Research and Development Program of China |
| 源URL | [http://ir.yic.ac.cn/handle/133337/41667]  |
| 专题 | 支撑部门_所级公共技术服务中心 |
| 通讯作者 | Li, Ke |
| 作者单位 | 1.Deraya Univ, Fac Pharm, Dept Pharmacognosy, New Minia 61111, Egypt 2.Minia Univ, Fac Pharm, Dept Pharmacognosy, Al Minya 61519, Egypt 3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 4.Univ Chinese Acad Sci, Coll Resources & Environm, Beijing 100049, Peoples R China 5.Northwest A&F Univ, Coll Chem & Pharm, Shaanxi Key Lab Nat Prod & Chem Biol, Yangling 712100, Peoples R China 6.Mansoura Univ, Fac Sci, Chem Dept, Mansoura 35516, Egypt |
| 推荐引用方式 GB/T 7714 | Zhang, Ran-Ran,Lu, Zhen,Shi, Qiang-Qiang,et al. Spiroconyone B and C, Two Rearranged Cholestane Steroids with Spiro[4.5]decane and Oxaspiro[4.5]decane Scaffolds from Patiria pectinifera[J]. JOURNAL OF NATURAL PRODUCTS,2025:9. |
| APA | Zhang, Ran-Ran.,Lu, Zhen.,Shi, Qiang-Qiang.,Yan, Zhi.,Abdelwahab, Ghada M..,...&Li, Ke.(2025).Spiroconyone B and C, Two Rearranged Cholestane Steroids with Spiro[4.5]decane and Oxaspiro[4.5]decane Scaffolds from Patiria pectinifera.JOURNAL OF NATURAL PRODUCTS,9. |
| MLA | Zhang, Ran-Ran,et al."Spiroconyone B and C, Two Rearranged Cholestane Steroids with Spiro[4.5]decane and Oxaspiro[4.5]decane Scaffolds from Patiria pectinifera".JOURNAL OF NATURAL PRODUCTS (2025):9. |
入库方式： OAI收割
来源：烟台海岸带研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。