DBDPE induces more persistent disturbances than BDE-209 in Crassostrea gigas: Gut microbiome-modulated physiological responses
文献类型：期刊论文
| 作者 | Liu, Lei1,3; Sun, Tao1,3; Ji, Chenglong1,2; Li, Fei1; Wu, Huifeng1,2 |
| 刊名 | AQUATIC TOXICOLOGY
 |
| 出版日期 | 2026 |
| 卷号 | 290页码:13 |
| 关键词 | Decabromodiphenyl ether Decabromodiphenyl ethane Bioaccumulation Gut microbiome Gut metabolome |
| ISSN号 | 0166-445X |
| DOI | 10.1016/j.aquatox.2025.107655 |
| 通讯作者 | Ji, Chenglong(clji@yic.ac.cn) ; Wu, Huifeng(hfwu@yic.ac.cn) |
| 英文摘要 | Decabromodiphenyl ether (BDE-209) and its alternative, decabromodiphenyl ethane (DBDPE), are brominated flame retardants (BFRs) globally distributed in marine environments, posing risks to marine organisms. The gut microbiome not only degrades BFRs but also undergoes BFR-induced compositional and host-microbe co-metabolic changes. In this study, Pacific oysters (Crassostrea gigas) were exposed to 1 and 100 mu g L-1 of BDE-209/ DBDPE for 28 days, followed by a 14-day depuration period. The higher bioaccumulation potential of DBDPE compared to BDE-209 might be attributed to its greater hydrophobicity, along with gut damage caused by pathogen proliferation. Alterations in the gut microbiome and metabolome induced by both BFR-exposure were associated with immunity and energy supply. Compared to BDE-209, DBDPE exposure induced more severe oxidative stress. Additionally, metabolomic analysis suggested that DBDPE has the potential to cause cell membrane damage. Notably, adverse effects, such as pathogen proliferation, persisted in DBDPE-exposed groups during depuration, which challenges its safer-alternative status. During depuration, functional remodeling in BFR-exposed oysters occurred through alterations in metabolism and genetic information processing in the gut microbiome, as well as alterations in purine metabolism, ABC transporters, and glycerophospholipid metabolism within the host (the latter being exclusive to the DBDPE-exposed groups). Despite its higher initial bioaccumulation, the higher elimination efficiency of DBDPE was facilitated by the activation of host repair program characterized by Verrucomicrobiota-mediated gut barrier restoration and glycerophospholipid metabolism-supported membrane remodeling. Correlation network analysis indicated that the adverse effects of high-concentration BFRs might be mediated by the gut microbiome, specifically through indole derivatives that may have upregulated the invertebrate form of AhR. Additionally, in the high-dose DBDPE-exposed group, a correlation between IAA and CAT suggested a potential link between microbial metabolism and the host's antioxidant system. This study provides comprehensive insights into gut microbiome and metabolome responses to BDE-209 and DBDPE, elucidating recovery mechanisms and the mediating role of gut microbiome in BFRinduced adverse effects in oysters. |
| WOS关键词 | DECABROMODIPHENYL ETHER BDE-209 ; BROMINATED FLAME RETARDANTS ; ARYL-HYDROCARBON RECEPTOR ; DIPHENYL ETHERS ; ETHANE ; BIOACCUMULATION ; OYSTER ; BIOTRANSFORMATION ; IDENTIFICATION ; DISRUPTION |
| WOS研究方向 | Marine & Freshwater Biology ; Toxicology |
| 语种 | 英语 |
| WOS记录号 | WOS:001631665500001 |
| 资助机构 | Key R & D Program of Shandong Province, China ; Fundamental Research Projects of Science and Technology Innovation and Development Plan in Yantai City ; Shandong Key Laboratory of Marine Ecological Restoration |
| 源URL | [http://ir.yic.ac.cn/handle/133337/41689]  |
| 专题 | 烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室 |
| 通讯作者 | Ji, Chenglong; Wu, Huifeng |
| 作者单位 | 1.Chinese Acad Sci, Shandong Key Lab Coastal Environm Proc, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 2.Qingdao Marine Sci & Technol Ctr, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266237, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Lei,Sun, Tao,Ji, Chenglong,et al. DBDPE induces more persistent disturbances than BDE-209 in Crassostrea gigas: Gut microbiome-modulated physiological responses[J]. AQUATIC TOXICOLOGY,2026,290:13. |
| APA | Liu, Lei,Sun, Tao,Ji, Chenglong,Li, Fei,&Wu, Huifeng.(2026).DBDPE induces more persistent disturbances than BDE-209 in Crassostrea gigas: Gut microbiome-modulated physiological responses.AQUATIC TOXICOLOGY,290,13. |
| MLA | Liu, Lei,et al."DBDPE induces more persistent disturbances than BDE-209 in Crassostrea gigas: Gut microbiome-modulated physiological responses".AQUATIC TOXICOLOGY 290(2026):13. |
入库方式： OAI收割
来源：烟台海岸带研究所
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