Vm-MSI: a Vancomycin-Antimicrobial Peptide Conjugate Combating Resistant Bacteria and Broadening the Antimicrobial Spectrum
文献类型：期刊论文
| 作者 | Li, Shuangyu3,4; Wang, Kang3,4; Shi, Wenzhuang3,4; Wang, Xu3,4; Li, Duxin3; Liu, Yanli3; Zhang, Peng2; Wang, Yipeng1,3,4 |
| 刊名 | ADVANCED SCIENCE
 |
| 出版日期 | 2025-12-08 |
| 页码 | 24 |
| 关键词 | antimicrobial peptide antimicrobial spectrum bacterial resistance structural modification vancomycin |
| DOI | 10.1002/advs.202503023 |
| 通讯作者 | Zhang, Peng(pcrole@foxmail.com) ; Wang, Yipeng(ypwang@yic.ac.cn) |
| 英文摘要 | Vancomycin is a critical last-resort treatment for multidrug-resistant Gram-positive bacteria, particularly severe methicillin-resistant S. aureus (MRSA) infections. However, the rise of vancomycin-resistant strains significantly compromises its therapeutic efficacy. To overcome this challenge, recent research has focused on structural modifications of vancomycin using diverse strategies. Herein, the potential of a modification strategy by coupling vancomycin with antimicrobial peptides (AMPs) that have different mechanisms of action is explored. Among the acquired conjugates, Vm-MSI showed a 20.18 fold improvement in antimicrobial activity over vancomycin and a 1.95 fold increase compared to the parent peptide MSI-78. Vm-MSI not only delays the development of resistance in vancomycin-resistant S. aureus (VRSA) but also exhibits potent activity against a wide range of Gram-negative bacteria. Additionally, Vm-MSI demonstrated strong synergy with several conventional antibiotics of distinct mechanisms and displayed potent activities in eradicating biofilms and persisters. Mechanistic studies revealed the complex antibacterial mechanisms of Vm-MSI, which hinder the development of bacterial resistance. In vivo, Vm-MSI displayed remarkable therapeutic efficacy in mouse models of VRSA-induced skin infection and multidrug-resistant A. baumannii-induced lung infection. These findings underscore the great potential of Vm-MSI as an effective treatment for infections caused by vancomycin-resistant and Gram-negative bacteria. |
| WOS关键词 | GRAM-NEGATIVE BACTERIA ; INFECTIONS ; MECHANISMS ; COMBINATION ; THERAPY |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001632259000001 |
| 资助机构 | National Natural Science Foundation of China ; Key Research & Development Plan in Social Development of Jiangsu Province ; Suzhou Agricultural Science and Technology Innovation Project |
| 源URL | [http://ir.yic.ac.cn/handle/133337/41928]  |
| 专题 | 海岸带生物学与生物资源利用重点实验室 |
| 通讯作者 | Zhang, Peng; Wang, Yipeng |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Soochow Univ, Affiliated Hosp 2, Dept Orthopaed, Suzhou 215004, Jiangsu, Peoples R China 3.Soochow Univ, Coll Pharmaceut Sci, Dept Biopharmaceut Sci, Suzhou 215123, Jiangsu, Peoples R China 4.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Shandong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Shuangyu,Wang, Kang,Shi, Wenzhuang,et al. Vm-MSI: a Vancomycin-Antimicrobial Peptide Conjugate Combating Resistant Bacteria and Broadening the Antimicrobial Spectrum[J]. ADVANCED SCIENCE,2025:24. |
| APA | Li, Shuangyu.,Wang, Kang.,Shi, Wenzhuang.,Wang, Xu.,Li, Duxin.,...&Wang, Yipeng.(2025).Vm-MSI: a Vancomycin-Antimicrobial Peptide Conjugate Combating Resistant Bacteria and Broadening the Antimicrobial Spectrum.ADVANCED SCIENCE,24. |
| MLA | Li, Shuangyu,et al."Vm-MSI: a Vancomycin-Antimicrobial Peptide Conjugate Combating Resistant Bacteria and Broadening the Antimicrobial Spectrum".ADVANCED SCIENCE (2025):24. |
入库方式： OAI收割
来源：烟台海岸带研究所
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