Metabolic modulation by antibiotic levofloxacin alters Cis-bifenthrin-induced neurotoxicity in amphibian tadpoles
文献类型：期刊论文
| 作者 | Ma, Yuqing1; Liu, Tingting1; Huang, Lei1; Zhang, Xiyu1; Wang, Wenjing2; Wang, Mengcen1; Wang, Qiangwei1 |
| 刊名 | ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
 |
| 出版日期 | 2025-12-01 |
| 卷号 | 308页码:13 |
| 关键词 | Synthetic pyrethroids Fluoroquinolones Neurotoxicity Metabolic interactions Co-exposure effects Xenopus laevis |
| ISSN号 | 0147-6513 |
| DOI | 10.1016/j.ecoenv.2025.119480 |
| 通讯作者 | Wang, Qiangwei(wqiangwei@zju.edu.cn) |
| 英文摘要 | Synthetic pyrethroids (SPs) and fluoroquinolones (FQs) are widely detected in aquatic environments and food chains, raising growing concern over their combined toxicity. However, the interaction between antibiotics and pesticides, particularly through host metabolism and microbiota, remains poorly understood. In this study, we investigated how the antibiotic levofloxacin (LEV) modulates cis-bifenthrin (cis-BF)-induced neurotoxicity in Xenopus laevis tadpoles. A 21-day co-exposure significantly impaired growth and locomotor behavior. Brain metabolomics revealed depletion of neuroprotective lipids (FAHFAs, PUFAs) and accumulation of potentially harmful organic acids and heterocycles. Transcriptomic analysis showed dysregulation of lipid metabolism, inflammation, and amino acid pathways. Given that LEV is a broad-spectrum antibiotic known to perturb gut microbiota composition, we speculated that its protective effects against cis-BF-induced neurotoxicity might involve modulation of the microbiota-gut-brain axis. Based on biochemical assays of intestinal tissues, LEV was found to mitigate cis-BF-induced oxidative stress and intestinal inflammation. However, 16S rRNA sequencing demonstrated microbiota alterations affecting SCFA- and amino acid- producing genera. Functional microbial shifts paralleled changes in brain metabolites, suggesting a microbiota-metabolism-neurotoxicity axis. This study demonstrates that although antibiotics can alleviate pesticide-induced intestinal inflammation, they concurrently exacerbate neurotoxicity, as evidenced by significant alterations in brain metabolites, transcriptomic profiles, and neurotransmitter levels. These findings highlight the complexity of microbial-metabolic interactions in environmental toxicology and the need for further investigation into their causal roles. |
| WOS关键词 | MICROBIOTA ; TOXICITY ; INSECTICIDES ; EXPOSURE ; PATHWAY |
| WOS研究方向 | Environmental Sciences & Ecology ; Toxicology |
| 语种 | 英语 |
| WOS记录号 | WOS:001634710700002 |
| 资助机构 | National Natural Science Foundation of China |
| 源URL | [http://ir.yic.ac.cn/handle/133337/41931]  |
| 专题 | 烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室 |
| 通讯作者 | Wang, Qiangwei |
| 作者单位 | 1.Zhejiang Univ, Inst Pesticide & Environm Toxicol, Minist Agr,Key Lab Mol Biol Crop Pathogens & Insec, Zhejiang Key Lab Biol & Ecol Regulat Crop Pathogen, Hangzhou 310058, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ma, Yuqing,Liu, Tingting,Huang, Lei,et al. Metabolic modulation by antibiotic levofloxacin alters Cis-bifenthrin-induced neurotoxicity in amphibian tadpoles[J]. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,2025,308:13. |
| APA | Ma, Yuqing.,Liu, Tingting.,Huang, Lei.,Zhang, Xiyu.,Wang, Wenjing.,...&Wang, Qiangwei.(2025).Metabolic modulation by antibiotic levofloxacin alters Cis-bifenthrin-induced neurotoxicity in amphibian tadpoles.ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,308,13. |
| MLA | Ma, Yuqing,et al."Metabolic modulation by antibiotic levofloxacin alters Cis-bifenthrin-induced neurotoxicity in amphibian tadpoles".ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 308(2025):13. |
入库方式： OAI收割
来源：烟台海岸带研究所
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