Current research into novel nano-delivery carriers based on exosomes: preparation, targeted enhancement, delivery mechanism and clinical application
文献类型：期刊论文
| 作者 | Zhu, Lin1,6; Qu, Jinqi5,6; Tian, Qiaoji6; Qin, Song5,6; Xu, Zongxi4; Zhang, Jian4; Lu, Chenyang2,3; Li, Wenjun1,6 |
| 刊名 | JOURNAL OF MATERIALS CHEMISTRY B
 |
| 出版日期 | 2025-12-02 |
| 页码 | 25 |
| ISSN号 | 2050-750X |
| DOI | 10.1039/d5tb02115d |
| 通讯作者 | Lu, Chenyang(luchenyang@nbu.edu.cn) ; Li, Wenjun() |
| 英文摘要 | As a group of natural nanocarriers, exosomes have become a hotspot for drug delivery research due to their biocompatibility, targeting, and ability to cross biological barriers. In this paper, we systematically review the biological properties, drug-carrying strategies, and delivery mechanisms of exosomes as delivery carriers. Studies have shown that exosomes have a unique double-layer membrane structure and abundant biological activities, which can realize efficient drug delivery by physical, chemical, and biological methods. Genetic engineering and chemical modifications can further optimize their targeting and delivery efficiency. Exosomes deliver bioactive molecules (e.g., proteins, nucleic acids) to recipient cells via mechanisms such as surface ligand-receptor recognition, membrane fusion, or endocytosis. This precise delivery system regulates cellular functions, evades immune clearance, and holds immense promise for disease treatment, showcasing broad clinical application prospects. However, this field still faces key technological bottlenecks such as large-scale production and quality control. To address these challenges, emerging technologies such as the EXODUS system and microfluidic chips, which have demonstrated significant advantages in enhancing extraction efficiency and purity, have been utilized, offering potential solutions for scalable and standardized production. Future research should focus on addressing issues related to production process standardization and clinical translation to promote the practical application of this novel delivery system. |
| WOS关键词 | MESENCHYMAL STEM-CELLS ; EXTRACELLULAR VESICLES ; ENGINEERING EXOSOMES ; IN-VITRO ; LOADED EXOSOMES ; CANCER ; THERAPY ; BIOGENESIS ; EFFICIENCY ; PACLITAXEL |
| WOS研究方向 | Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001639451300001 |
| 资助机构 | Shandong Provincial Natural Science Foundation |
| 源URL | [http://ir.yic.ac.cn/handle/133337/41934]  |
| 专题 | 海岸带生物学与生物资源利用重点实验室 |
| 通讯作者 | Lu, Chenyang; Li, Wenjun |
| 作者单位 | 1.Shandong Univ Tradit Chinese Med, Qingdao Acad Chinese Med Sci, Qingdao 266112, Peoples R China 2.Ningbo Univ, Sch Marine Sci, Ningbo 315211, Peoples R China 3.Ningbo Univ, State Key Lab Managing Biot & Chem Threats Qual &, Ningbo 315211, Peoples R China 4.Qingdao Langyatai Grp Co Ltd, Qingdao 266400, Peoples R China 5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 6.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhu, Lin,Qu, Jinqi,Tian, Qiaoji,et al. Current research into novel nano-delivery carriers based on exosomes: preparation, targeted enhancement, delivery mechanism and clinical application[J]. JOURNAL OF MATERIALS CHEMISTRY B,2025:25. |
| APA | Zhu, Lin.,Qu, Jinqi.,Tian, Qiaoji.,Qin, Song.,Xu, Zongxi.,...&Li, Wenjun.(2025).Current research into novel nano-delivery carriers based on exosomes: preparation, targeted enhancement, delivery mechanism and clinical application.JOURNAL OF MATERIALS CHEMISTRY B,25. |
| MLA | Zhu, Lin,et al."Current research into novel nano-delivery carriers based on exosomes: preparation, targeted enhancement, delivery mechanism and clinical application".JOURNAL OF MATERIALS CHEMISTRY B (2025):25. |
入库方式： OAI收割
来源：烟台海岸带研究所
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