Acute disturbance, but chronic re-equilibration of the oyster metabolome to 17β-estradiol and nonylphenol exposure
文献类型：期刊论文
| 作者 | Kumar, Sazal3; O'connor, Wayne A.2; Luengen, Allison C.1; Leusch, Frederic D. L.6; Melvin, Steve D.6; Ji, Chenglong3,5; Zhan, Junfei3,4; MacFarlane, Geoff R.3 |
| 刊名 | AQUATIC TOXICOLOGY
 |
| 出版日期 | 2026-02-01 |
| 卷号 | 291页码:11 |
| 关键词 | 17 beta-estradiol Nonylphenol Acute exposure Chronic exposure Adaptive response Oyster Depuration |
| ISSN号 | 0166-445X |
| DOI | 10.1016/j.aquatox.2025.107663 |
| 通讯作者 | MacFarlane, Geoff R.(geoff.macfarlane@newcastle.edu.au) |
| 英文摘要 | In estuaries, aquatic organisms are often exposed to estrogenic endocrine disrupting chemicals (EEDCs), including 17(3-estradiol (E2) and nonylphenol (NP), which affect physiology and metabolism. This study evaluated metabolic profiles of Sydney rock oysters (Saccostrea glomerata) using 1HNMR -based metabolomics after acute (14 days), pulse (14 days exposure followed by 14 days depuration), and chronic (28 days) exposure of E2 at 200 ng/L and NP at 5000 ng/L. Only acute exposure to both E2 and NP led to marked metabolic perturbations. Energy and stress-related metabolites including adenosine monophosphate, succinate, acetoacetate, and glutamate significantly increased in acute treatments compared to controls, suggesting heightened energy demand to cope with oxidative and osmotic stress. However, the metabolites from pulse and chronic exposure treatments were not significantly different from the control. Such responses highlight a time-dependent adaptation of molluscs, similar to depuration. E2 is expected to be more rapidly metabolised in molluscs than NP, leading to comparatively slower metabolic adaptation of molluscs to NP exposure. Finally, this study emphasizes that oysters have a time-dependent adaptive mechanism to cope with EEDC exposure. |
| WOS关键词 | MUSSEL MYTILUS-GALLOPROVINCIALIS ; ENDOCRINE DISRUPTING CHEMICALS ; ACTIVATED PROTEIN-KINASE ; SYDNEY ROCK OYSTER ; PACIFIC OYSTER ; SACCOSTREA-GLOMERATA ; GENE-EXPRESSION ; MARINE BIVALVE ; WASTE-WATER ; FRESH-WATER |
| WOS研究方向 | Marine & Freshwater Biology ; Toxicology |
| 语种 | 英语 |
| WOS记录号 | WOS:001636032600001 |
| 资助机构 | Australian Research Council ; Hunter Water Corporation ; NSW Department of Primary Industries ; Australian Research Council |
| 源URL | [http://ir.yic.ac.cn/handle/133337/41940]  |
| 专题 | 烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室 |
| 通讯作者 | MacFarlane, Geoff R. |
| 作者单位 | 1.Univ San Francisco, Dept Environm Sci, San Francisco, CA 94117 USA 2.Port Stephens Fisheries Inst, New South Wales Dept Primary Ind, Taylors Beach, NSW 2316, Australia 3.Univ Newcastle UoN, Sch Environm & Life Sci, Callaghan, NSW 2308, Australia 4.Ludong Univ, Key Lab Ecol Restorat & Conservat Coastal Wetlands, Inst Adv Study Coastal Ecol, Yantai 264025, Peoples R China 5.Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China 6.Griffith Univ, Australian Rivers Inst, Sch Environm & Sci, Southport, Qld 4222, Australia |
| 推荐引用方式 GB/T 7714 | Kumar, Sazal,O'connor, Wayne A.,Luengen, Allison C.,et al. Acute disturbance, but chronic re-equilibration of the oyster metabolome to 17β-estradiol and nonylphenol exposure[J]. AQUATIC TOXICOLOGY,2026,291:11. |
| APA | Kumar, Sazal.,O'connor, Wayne A..,Luengen, Allison C..,Leusch, Frederic D. L..,Melvin, Steve D..,...&MacFarlane, Geoff R..(2026).Acute disturbance, but chronic re-equilibration of the oyster metabolome to 17β-estradiol and nonylphenol exposure.AQUATIC TOXICOLOGY,291,11. |
| MLA | Kumar, Sazal,et al."Acute disturbance, but chronic re-equilibration of the oyster metabolome to 17β-estradiol and nonylphenol exposure".AQUATIC TOXICOLOGY 291(2026):11. |
入库方式： OAI收割
来源：烟台海岸带研究所
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