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Cationic Surface Modification Combined with Collagen Enhances the Stability and Delivery of Magnetosomes for Tumor Hyperthermia

文献类型：期刊论文

作者Wang, Yu1,4; Lin, Conghao5; Zhang, Yubing3; Li, Wenjun1; Cui, Hongli1; Li, Bohan6; Liu, Zhengyi1; Wang, Kang1; Wang, Qi1; Wang, Yinchu1
刊名JOURNAL OF FUNCTIONAL BIOMATERIALS
出版日期2025-12-12
卷号16期号:12页码:17
关键词cationic modification collagen delivery efficiency magnetosomes suspension stability tumor magnetic hyperthermia
DOI10.3390/jfb16120461
通讯作者Zhuang, Hongqin(hqzhuang@nju.edu.cn) ; Qin, Song(sqin@yic.ac.cn)
英文摘要Magnetosomes (MTS), membrane-enclosed magnetic nanoparticles naturally biomineralized by magnetotactic bacteria, are promising materials for tumor hyperthermia owing to their good biocompatibility and heating efficiency. However, their application is limited by poor suspension stability and low injectability at high concentrations. This study aimed to enhance magnetosome stability and delivery performance through surface cationization combined with collagen matrix stabilization. The resulting cationic magnetosomes (CMTS) exhibited an increased positive charge on the outer membrane. Collagen, functioning as a negatively charged matrix under mildly alkaline conditions, effectively stabilized the cationic magnetosomes, forming CMTS-collagen aqueous suspensions (CMTS-Colas) that remained well-suspended for over 24 h and could be easily resuspended after 10 days of storage. Compared with native magnetosome suspensions, CMTS in collagen displayed smaller hydrodynamic diameters and significantly improved injectability through 26G and 31G fine needles. Under an alternating magnetic field, 2 mg/mL CMTS-Colas efficiently induced over 98% apoptosis in hepatoma cells after two treatment sessions and led to complete loss of cell viability after three sessions. These findings demonstrate that CMTS-Colas substantially improve the suspension stability and injectability of magnetosomes while maintaining strong hyperthermic efficacy, suggesting a promising strategy for stabilizing magnetosomes and potentially benefiting other charged, aggregation-prone magnetic biomaterials.
WOS关键词MAGNETOTACTIC BACTERIA ; NANOPARTICLES
WOS研究方向Engineering ; Materials Science
语种英语
WOS记录号WOS:001646798400001
资助机构Science and Technology Major Project of Yantai City ; Special Plan for Major Scientific and Technological Innovation in Qingdao West ; International Partnership Program of Chinese Academy of Sciences for Grand Challenges ; National Natural Science Foundation of China ; Changchun Branch of Chinese Academy of Sciences ; Joint Funds of the National Natural Science Foundation of China and Shandong Province
源URL[http://ir.yic.ac.cn/handle/133337/41973]  
专题海岸带生物学与生物资源利用重点实验室
通讯作者Zhuang, Hongqin; Qin, Song
作者单位1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Biol Resource Utilizat, Yantai 264003, Peoples R China
2.China Univ Petr East China, State Key Lab Heavy Oil Proc, Qingdao 266580, Peoples R China
3.Nanjing Univ, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Nanjing 210023, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
5.Southeast Univ, Natl Demonstrat Ctr Expt Biomed Engn Educ, Sch Biol Sci & Med Engn, State Key Lab Bioelect, Nanjing 210096, Peoples R China
6.Binzhou Med Univ, Sch Tradit Chinese Med, Featured Lab Biosynth & Target Discovery Act Compo, Yantai 264003, Peoples R China
7.Yantai Univ, Sch Life Sci, Yantai 264003, Peoples R China
8.China Univ Petr East China, Coll Chem & Chem Engn, Ctr Bioengn & Biotechnol, Qingdao 266580, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Yu,Lin, Conghao,Zhang, Yubing,et al. Cationic Surface Modification Combined with Collagen Enhances the Stability and Delivery of Magnetosomes for Tumor Hyperthermia[J]. JOURNAL OF FUNCTIONAL BIOMATERIALS,2025,16(12):17.
APA Wang, Yu.,Lin, Conghao.,Zhang, Yubing.,Li, Wenjun.,Cui, Hongli.,...&Qin, Song.(2025).Cationic Surface Modification Combined with Collagen Enhances the Stability and Delivery of Magnetosomes for Tumor Hyperthermia.JOURNAL OF FUNCTIONAL BIOMATERIALS,16(12),17.
MLA Wang, Yu,et al."Cationic Surface Modification Combined with Collagen Enhances the Stability and Delivery of Magnetosomes for Tumor Hyperthermia".JOURNAL OF FUNCTIONAL BIOMATERIALS 16.12(2025):17.

入库方式： OAI收割

来源：烟台海岸带研究所

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